数字中医药（英文）2022，Vol.5Issue(1)：59-67,9.DOI:10.1016/j.dcmed.2022.03.006
针刺子宫穴的静息态自发脑活动及功能连接分析
Research on resting spontaneous brain activity and functional connectivity of acupuncture at uterine acupoints
摘要
Abstract
Objective The resting-state functional magnetic resonance imaging (rs-fMRI) method was used to observe brain activity and its functional connection upon electroacupuncture stimu-lation at bilateral uterine acupoints (EX-CA1), as well as to investigate the mechanism of acu-puncture in the treatment of gynecological diseases.Methods Twenty-two healthy female subjects were stimulated by electroacupuncture at bi-lateral uterine acupoints; rs-fMRI data of the brain were acquired and standardized. Degree centrality (DC), amplitude of low-frequency fluctuation (ALFF), and regional homogeneity (ReHo) were used to analyze local spontaneous brain activity via acupuncture. An independ-ent component analysis was used to evaluate the functional connectivity of the resting brain networks after acupuncture. Results Analytical results showed that the neural activity intensity of the precuneus lobe, or-bitofrontal cortex, lingual gyrus, amygdala, and posterior central gyrus decreased after acupuncture (voxel P < 0.001, cluster P < 0.05). Functional connectivity analysis revealed weakened auditory and right frontal-parietal networks (voxel P < 0.001, cluster P < 0.05), en-hanced visual network (voxel P < 0.001, cluster P < 0.05), and synergistic auditory network and hypothalamic-pituitary system. Conclusion Significant differences in neural activity and functional connectivity in specific brain regions were observed after acupuncture intervention at uterine acupoints; the hypo-thalamic-pituitary system also showed various active states in different brain regions. It is speculated that the effective mechanism of acupuncture at uterine acupoints is related to the regulation of reproductive hormones, emotional changes, and somatic sensations. Therefore, the methods used in this study could clarify the neural mechanism of uterine-point acupunc-ture in the treatment of gynecological diseases and may serve as a reference for other studies pertaining to acupuncture.关键词
子宫穴/针刺/功能磁共振成像/局部自发性脑活动分析/静息态/功能连接分析Key words
Uterine acupoints/Acupuncture/Functional magnetic resonance imaging/Local spontaneous brain activity analysis/Resting state/Functional connectivity引用本文复制引用
袁航,于晓华,李翔,秦嗣钧,梁桂香,白田雨,魏本征..针刺子宫穴的静息态自发脑活动及功能连接分析[J].数字中医药（英文）,2022,5(1):59-67,9.基金项目
National Nature Science Foundation of China(61872225),Natural Science Foundation of Shandong Province(ZR2020KF013,ZR2020ZD44,ZR2019ZD04,and ZR2020QF043),Introduction and Cultivation Program for Young Creative Talents in Colleges and Universities of Shandong Province(2019-173),and Special Fund of Qilu Health and Health Leading Talents Training Project. （61872225）
