数字中医药（英文）2022，Vol.5Issue(1)：68-74,7.DOI:10.1016/j.dcmed.2022.03.007
六味地黄复方三种不同剂型之间的组分传递规律研究
The components transitive regularity of three dosage forms of Liuwei Dihuang Fufang
摘要
Abstract
Objective To explore the transitive regularity of holistic constituents from the crude slices of the medicinal raw materials (MCS) to the formula granules (FG), fufang decoction (FD), and finally, the concentrated pills (CP) of Liuwei Dihuang Fufang (六味地黄复方, LWDHF).Methods Samples for MCS, FG, FD, and CP of LWDHF were obtained, and a fingerprint data-base was established using high-performance liquid chromatography (HPLC), by separating the samples in an XB-C18 column and analyzing the transitive regularity of components us-ing the total quantum statistical moment (TQSM), including total quantum zero moment (AUCT), total quantum first moment (MRTT), total quantum second moment (VRTT), and its similarity approach. The AUCT, MRTT, and VRTT were calculated based on the representative HPLC chromatograms of FG, FD, and CP of LWDHF. Results AUCT of FG, FD, and CP of LWDHF was 71804, 46553, and 144646 μV·s, respectively;MRTT was 14.43, 14.54, and 18.85 min, respectively; and VRTT was 106.98, 112.84, and 269.12 min2, respectively. Comparing the similarity of FG/FD, FG/CP and FD/CP of LWDHF, the TQSM similarity values were 98.66％, 76.62％, and 75.37％, respectively, whereas the tradi-tional similarity evaluation values were 98.68％, 85.43％, and 85.60％, respectively. Conclusion The results perform little distinction in the total composition between FG and FD, whereas some distinction existed between FD and CP. Experimental evidence, therefore indicates that FG could be used as the alternative of MCS in clinical applications.关键词
六味地黄复方/配方颗粒/方汤/浓缩片/总量统计矩/高效液相色谱/组分传递规律Key words
Liuwei Dihuang Fufang (六味地黄复方, LWDHF)/Formula granules/Fufang decoction/Concentrated pills/Total quantum statistical moment/(TQSM)/High-performance liquid chromato-/graphy (HPLC)/Component transitive regularity引用本文复制引用
朱俊平,张喜利,赵靖,梁慧慧,李原华,刘文龙..六味地黄复方三种不同剂型之间的组分传递规律研究[J].数字中医药（英文）,2022,5(1):68-74,7.基金项目
Hunan Provincial Natural Science Foundation of China(2019JJ40220 and 2021JJ30514),Hunan Provincial Ad-ministration of Traditional Chinese Medicine(2021204 and 2021073),Scientific Research Fund of Hunan Provin-cial Education Department(2021204 and 2021073),and Pharmaceutical Open Fund of Domestic First-class Dis-ciplines(Cultivation)of Hunan Province(2018YX11). （2019JJ40220 and 2021JJ30514）
