分析测试学报2022，Vol.41Issue(4)：443-453,11.DOI:10.19969/j.fxcsxb.22010604
蛋白质组驱动的精准医学研究进展
Recent Progress of Proteomics-driven Precision Medicine
摘要
Abstract
Proteins involve in virtually all cell functions and participate in a variety of metabolic and physiological pro?cesses. Proteomics, which systematically analyzes the protein expression levels, modification states of proteins, and intracellular protein-protein interactions, provides a global perspective on how these molecules changes at differ?ent stages of disease occurrence and development.Recently,clinical proteomics has been proven to play a significant role in early diagnosis, prognosis, and monitoring of disease development. The concept of proteomics-driven preci?sion medicine has been proposed thereby. In this review, the progress of proteomics-driven precision medicine (PDPM)and its application in the studies of major diseases are summarized.关键词
蛋白质组学/质谱/生物标志物/蛋白质组学驱动的精准医学(PDPM)Key words
proteomics/mass spectrometry/biomarker/proteomics-driven precision medicine(PDPM)分类
化学化工引用本文复制引用
张磊,王晓宇,张莹,陆豪杰..蛋白质组驱动的精准医学研究进展[J].分析测试学报,2022,41(4):443-453,11.基金项目
Foundation item:National Key Research and Development Program of China(2020YFE0202200) （2020YFE0202200）
NSF of China(Grants 21974026 and 22174021) （Grants 21974026 and 22174021）
