分析测试学报2022，Vol.41Issue(4)：476-485,10.DOI:10.19969/j.fxcsxb.21120704
纳米尺度MOFs在肿瘤及肿瘤标志物生物学成像中的研究进展
Recent Progress in Nanoscale MOFs for Bio?logical Imaging of Tumors and Tumor Markers
摘要
Abstract
Metal-organic frameworks(MOFs)have played important roles in a wide range of fields,such as gas stor?age and separation,fuel cells,energy conversion,and chemical/biological sensors.When one of the dimensions is scaled down to nanometer,MOFs can be named as nanoscale MOFs(nMOFs).Compared with the traditional MOFs, nMOFs retain the advantages of highly ordered porosity, structural tunability, more effective surface modification sites and improved biological distributions.nMOFs are biocompatible molecular nanomaterials with great potentials in various biomedical applications, especially for detection of tumors and tumor markers. In this review, recent prog?ress in nMOFs for biological imaging of tumors and tumor markers is summarized.Different bioimaging techniques in?cluding fluorescence imaging,magnetic resonance imaging(MRI),photoacoustic imaging(PAI),computed tomogra?phy imaging(CTI), positron emission tomography imaging(PETI)are introduced. After that, multimodal imaging superimposed by two or more imaging modalities is highlighted. Finally,a brief conclusion about this special field is provided.Priorities of research in nMOF-mediated therapies and the prospects of clinical applications of nMOFs as de?livery carriers and cancer therapeutics are also outlined.This review is expected to advance our understanding of this special field,and promote the applications of nMOFs in early diagnosis of disease and tumor therapy .关键词
纳米金属有机框架/生物成像/肿瘤标志物/生物医药Key words
nanoscale metal-organic frameworks(nMOFs)/biological imaging/tumor markers/biomedicine分类
化学化工引用本文复制引用
廖学巍,刘旸,王琛..纳米尺度MOFs在肿瘤及肿瘤标志物生物学成像中的研究进展[J].分析测试学报,2022,41(4):476-485,10.基金项目
Foundation item:the National Natural Science Foundation of China(22022412,21874155,22104060) （22022412,21874155,22104060）
the Natural Science Foundation of Jiangsu Province(BK20200716,BK20191316) （BK20200716,BK20191316）
the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(20KJB150019) （20KJB150019）
Innovation and Entrepreneurship Doctor Program of Jiangsu Province(JSSCBS20210317) （JSSCBS20210317）
the State Key Laboratory of Analytical Chemistry for Life Science(SKLACLS2106) （SKLACLS2106）
the Qing-Lan Project of Jiangsu Province(2019) （2019）
