分析测试学报2022，Vol.41Issue(4)：486-497,12.DOI:10.19969/j.fxcsxb.21121303
基于i-motif的生物医学应用纳米系统:pH成像、药物控释和肿瘤诊疗
I-Motif-based Nanosystems for Biomedical Appli?cations:pH Imaging,Drugs Controlled Release and Tumor Theranostics
摘要
Abstract
I-motif,as a novel pH-sensitive element,has attracted extensive attention and research upsurge in the field of biomedicine due to its ability of fast conformation alteration at different pH conditions,as well as the advantages of au?tomatic synthesis,excellent biocompatibility and flexible functional integration.In this review,the basic performances of i-motif are firstly described. Then, the applications of i-motif-based nanosystems in biomedical field are reviewed from three aspects of cellular pH imaging, pH-controlled drugs release and pH-responsive tumor theranostics applica?tions.Finally,some of the current challenges of the i-motif-based nanosystems for the biomedical applications are point?ed out,and an insight into the future prospects of i-motif-based nanosystems for precision medicine is provided .关键词
i-motif/pH成像/pH控制的药物释放/pH响应型肿瘤诊疗Key words
i-motif/pH imaging/pH-controlled drugs release/pH-responsive tumor theranostics分类
化学化工引用本文复制引用
马文杰,黄金,程洪,贾瑞晨,陈彪,孙欢欢,吴宇辰,何晓晓,王柯敏..基于i-motif的生物医学应用纳米系统:pH成像、药物控释和肿瘤诊疗[J].分析测试学报,2022,41(4):486-497,12.基金项目
Fundation item:the Natural Science Foundation of China(21735002,21874035,21675046,22174044) （21735002,21874035,21675046,22174044）
Postgraduate Scientific Research Innovation Project of Hunan Province(CX20210396) （CX20210396）
