苦参碱新类似物的合成和抗肿瘤活性研究OA
Synthesis of Novel Analogues of Matrine and Anti-Tumor Activity Assessment
合成了一系列苦参碱分子内酰胺部分开环的新类似物.体外细胞毒性研究表明,结构中含有萘环和苯甲酰基类似物的化合物C4,与其母体化合物苦参碱及其他内酰胺开环类似物相比,具有最佳的抗增殖活性.综上,文章发现了一个潜在的抗肿瘤先导化合物C4,该化合物可用于进一步的体内外抗肿瘤研究.
In this article ,a series of matrine analogues with ring-opening in the lactam portion of the molecule were synthesized and assessed against four cancer cell lines .The in vitro cytotoxicity study exhibited that analogue C4 with a naphthyl ring displayed the best antiproliferative activity compared to its parent compound matrine and other lactam ring-opening analogues .Taken together ,the anti-tumor potential lead compound C4 was discovered ,which coul…查看全部>>
钱明成;江欣育;戚颖;刘慧敏;周阔;赵帅;陈新
常州大学药学院,江苏常州213164常州大学药学院,江苏常州213164常州大学药学院,江苏常州213164常州大学药学院,江苏常州213164常州大学药学院,江苏常州213164常州大学药学院,江苏常州213164常州大学药学院,江苏常州213164
医药卫生
苦参碱构效关系抗肿瘤
matrinestructure activity relationshipanti-tumor activity
《常州大学学报（自然科学版）》 2022 (2)
81-86,6
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