中山大学学报（自然科学版）（中英文）2022，Vol.61Issue(3)：11-20,10.DOI:10.13471/j.cnki.acta.snus.2021E010
健康成年小鼠和AD模型小鼠在GABA受体调节后脑电与记忆的不同相关模式
Different correlation patterns between EEG and memory after GABA receptor adjustment in normal middle-aged mice and AD model mice
摘要
Abstract
Symptoms including brain atrophy, neuronal loss, neurotansmitter imbalance and cogni-tive decline are generally associated with Alzheimer's disease(AD), also occur in normal aging. Thus, comparing the differences between normal aging and AD is of interest to test the accelerated aging hypothesis of AD. An imbalance between excitatory/inhibitory (E/I) neurotransmission especially that originated from the dysfunction in gamma-aminobutyric acid (GABA) inhibition is involved in both AD and normal aging. In the present study, we performed correlation analyses between electroencepha-lograms (EEGs) and memory in middle-aged (～12 months old) wild-type mice (WT) and AD model mice (APP/PS1) after E/I balance adjustment via GABAA agonist muscimol and antagonist bicuculline administration (0. 1 mg/kg intraperitoneally). Specifically, EEGs of the hippocampus and prefrontal cortex were recorded during Y-maze performance. Overall, WT and AD mice showed different correla-tion patterns between EEG activity and behavioral memory performance. Significant correlations were observed in EEG activity across a wider range of frequency bands (2-100 Hz, except 4-8 Hz) in WT mice, but were mainly observed in low frequency bands (delta-theta, 2-8 Hz) in AD mice. In addition, muscimol and bicuculline treatment contributed to better brain function in AD mice;in contrast, bicu-culline administration resulted in poorer brain function in WT mice. Thus, our study indicates that AD pathology is distinct from the normal aging process, and the data may not support the accelerated aging hypothesis of AD. Importantly, this work reveals new insights into future AD treatment by influencing low-frequency EEG activity through E/I balance adjustment, thereby aiding cognitive recovery.关键词
衰老加速/阿尔茨海默病(Alzheimer's disease,AD)/bicuculline/GABAA/muscimol/空间记忆Key words
aging acceleration/Alzheimer's disease (AD)/bicuculline/GABAA/muscimol/spatial memory分类
生物科学引用本文复制引用
周正,李连娥,段梦思,孙华英,易虎,付玉..健康成年小鼠和AD模型小鼠在GABA受体调节后脑电与记忆的不同相关模式[J].中山大学学报（自然科学版）（中英文）,2022,61(3):11-20,10.基金项目
国家自然科学基金(81760258,81560221,81703497,61972158) （81760258,81560221,81703497,61972158）
云南省自然科学基金(2017FB125,2017FD067) （2017FB125,2017FD067）
