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Absolute bioavailability,dose proportionality,and tissue distribution of rotundic acid in rats based on validated LC-QqQ-MS/MS method

Haihua Shang Duanyun Si Xiaohan Dai Mi Li Yueyi Kai Zerong Liu Min Wang Quansheng Li Yuan Gu Changxiao Liu

药物分析学报（英文）2022，Vol.12Issue(2)：278-286,9.

Absolute bioavailability,dose proportionality,and tissue distribution of rotundic acid in rats based on validated LC-QqQ-MS/MS method

Haihua Shang ¹Duanyun Si ²Xiaohan Dai ²Mi Li ³Yueyi Kai ²Zerong Liu ²Min Wang ²Quansheng Li ²Yuan Gu ²Changxiao Liu²

作者信息

1. School of Pharmacy,Shenyang Pharmaceutical University,Shenyang,110016,China
2. State Key Laboratory of Drug Delivery and Pharmacokinetics,Tianjin Institute of Pharmaceutical Research,Tianjin,300301,China
3. Research Unit for Drug Metabolism,Chinese Academy of Medical Sciences,Tianjin,300301,China
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摘要

关键词

Rotundic acid/LC-QqQ-MS/MS/Bioavailability/Tissue distribution/Pharmacokinetics/Dose proportionality

Key words

Rotundic acid/LC-QqQ-MS/MS/Bioavailability/Tissue distribution/Pharmacokinetics/Dose proportionality

引用本文复制引用

Haihua Shang,Duanyun Si,Xiaohan Dai,Mi Li,Yueyi Kai,Zerong Liu,Min Wang,Quansheng Li,Yuan Gu,Changxiao Liu..Absolute bioavailability,dose proportionality,and tissue distribution of rotundic acid in rats based on validated LC-QqQ-MS/MS method[J].药物分析学报（英文）,2022,12(2):278-286,9.

基金项目

This study was supported by CAMS Innovation Fund for Medical Sciences(Grant No.:2019-I2M-5-020),the National Natural Sci-ence Foundation of China(Grant No.:81503154),and the National Major Scientific and Technological Special Project for Significant New Drugs Development(Grant No.:2017ZX09101002-001-005). （Grant No.:2019-I2M-5-020）

药物分析学报（英文）

OACSCDSCI

ISSN：2095-1779

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