数字中医药（英文）2022，Vol.5Issue(2)：123-140,18.DOI:10.1016/j.dcmed.2022.06.003
基于数据挖掘分析芳香中药治疗心绞痛古今用药规律
Ancient and modern medication laws of aromatic Chinese medicines in treating angina pectoris based on data mining
摘要
Abstract
Objective To explore ancient and modern medication laws of aromatic Chinese medicines in treating angina pectoris, and to provide new ideas for the clinical treatment. Methods With "angina pectoris" as the key word, ancient books prescriptions and Chinese patent medicines related to angina pectoris were collected from China National Knowledge Infrastructure (CNKI), Traditional Chinese Medicine Database System, Chinese Medicine Prescription Database, New National Proprietary Chinese Medicine (2nd edition), and Chinese Pharmacopoeia (2020 edition) from January 1, 2015 to December 31, 2021. Core high-frequency aromatic Chinese medicines were defined, and their potential medication rules were analyzed and summarized. Microsoft Access 2010 was used for data management. Data analysis software, including Excel and IBM SPSS Modeler 18.0 were used for drug association rule analysis, and Cytoscape 3.7.2 for visual display. Results There were 67 ancient books prescriptions and 258 Chinese patent medicines con-taining aromatic Chinese medicines treating angina pectoris collected from relevant data-bases. In ancient books prescriptions, there were nine aromatic Chinese medicines with the frequency ≥10, and the most commonly used medicine was Danggui (Angelicae Sinensis Radix), followed by Chenpi (Citri Reticulatae Pericarpium). There were 33 aromatic Chinese medicines with the frequency ≥10 in Chinese patent medicines, and the most commonly used medicine was Danshen (Salviae Miltiorrhizae Radix et Rhizoma), followed by Chuanxiong (Chuanxiong Rhizoma) and Sanqi (Notoginseng Radix et Rhizoma). In ancient books prescriptions, the medicines mainly belonged to intenal-warming medicines, Qi-regu-lating medicines, and blood circulation promoting and blood stasis removing medicines. There were eight medicine pairs with confidence equal to 100％ in ancient books prescriptions, the most frequently used pairs were Chuanxiong (Chuanxiong Rhizoma) +Danggui (Angelicae Sinensis Radix), and Xiangfu (Cyperi Rhizoma) + Chenpi (Citri Reticu-latae Pericarpium). In Chinese patent medicines, the aromatic Chinese medicine Chuanxiong (Chuanxiong Rhizoma) could be combined with many other Chinese medicines, among which the Confidence and Support of Chuanxiong (Chuanxiong Rhizoma) + Danshen (Salvi-ae Miltiorrhizae Radix et Rhizoma) were at a high level. Conclusion Aromatic Chinese medicines for the treatment of angina pectoris of coronary heart disease are mainly warm, and the flavors are mainly pungent, sweet, and bitter. They mainly access to the liver, gallbladder, and pericardium meridians. The treatment of angina pectoris of coronary heart disease mainly focuses on warming heart pulse, and promoting blood circulation and removing blood stasis.关键词
芳香中药/古籍方剂/中成药/心绞痛/用药规律/川芎Key words
Aromatic Chinese medicines/Ancient books prescriptions/Chinese patent medicines/Angina pectoris/Medication laws/Chuanxiong (Chuanxiong Rhizoma)引用本文复制引用
王朝平,罗晶,万强,曹美芳,查青林,雷志强,Abid Naeem,杨明..基于数据挖掘分析芳香中药治疗心绞痛古今用药规律[J].数字中医药（英文）,2022,5(2):123-140,18.基金项目
Jiangxi Provincial Department of Science and Techno-logy Major Research and Development Program(20194ABC28009 and 20202BBGL73008),and National Key Research and Development Program(2018YFC1706404) （20194ABC28009 and 20202BBGL73008）
