数字中医药（英文）2022，Vol.5Issue(2)：141-153,13.DOI:10.1016/j.dcmed.2022.06.004
国医大师周仲瑛辨治甲状腺癌医案集内关联解析研究
Intra-set correlation analysis of medical records of thyroid cancer treated by traditional Chinese medicine Master ZHOU Zhongying
摘要
Abstract
Objective Based on intra-set correlation analysis, this paper deconstructs the clinical medic-al records of traditional Chinese medicine (TCM) Master ZHOU Zhongying in treating thyroid cancer, and analyzes the experience in "mechanism-syndrome-medicine-prescription" for thyroid cancer. Methods Through Medcase data processing platform, based on Frequent Pattern (FP)-Growth enhanced correlation analysis algorithm, the medical records of Professor ZHOU Zhongying for the treatment of thyroid cancer from June 1, 2001 to February 28, 2015 were analyzed within the set. Results This study involved 43 medical records, 43 patients, and 167 visits. After processing intra-set correlations, 28 groups of highly correlated symptoms, 21 groups of highly correl-ated tongue images, 10 groups of highly correlated pulse conditions, 28 groups of highly cor-related pathogenesis, 34 groups of highly correlated herbs, and 26 groups of highly correlated western medicine diagnosis were selected. Professor ZHOU Zhongying treats thyroid cancer according to syndrome differentiation. Symptoms with more association rules included neck swelling, neck pain, cough, and dry mouth; tongue images with more association rules in-cluded dark purple tongue, dark red tongue, and fissured tongue; pulse conditions with more association rules were wiry pulse, thready pulse, small pulse, and slippery pulse; the patho-genesis with more association rules was phlegm and blood stasis, damp-heat accumulation, and impairment of both Qi and Yin; herbs with more association rules were Chaihu (Bupleuri Radix), Zeqi (Sun Euphoribiae Herb), and Tiandong (Asparagi Radix); western medicine dia-gnosis with more association rules included thyroid cancer, insomnia, and chronic gastritis. Conclusion Thyroid cancer mostly presents as deficiency in origin and excess in manifesta-tions. The basic pathogenesis is phlegm and blood stasis, damp-heat accumulation, and impairment of both Qi and Yin, which are closely related to liver, kidney, and spleen. Profess-or ZHOU Zhongying adopts both attack and supplement approaches as the general treat-ment principle, with a strong emphasis on regulating Qi and relieving depression, eliminat-ing phlegm and resolving stagnation, eliminating dampness and turbidity, clearing fire and destroying poison, moistening dryness and softening hard mass, invigorating Qi and nourish-ing Yin, and paying attention to nourishing liver and kidney, invigorating spleen and stomach, while protecting the heart and lungs.关键词
国医大师/周仲瑛/甲状腺癌/经验分析/数据挖掘/集内关联/痰瘀互结/湿热内蕴/攻补兼施Key words
Traditional Chinese medicine Master/ZHOU Zhongying/Thyroid cancer/Empirical analysis/Data mining/Intra-set association/Phlegm and blood stasis/Damp-heat accumulation/Combination of attack and supplement引用本文复制引用
徐子缘,朱垚,陆明,周仲瑛..国医大师周仲瑛辨治甲状腺癌医案集内关联解析研究[J].数字中医药（英文）,2022,5(2):141-153,13.基金项目
Six Talent Peak Projects in Jiangsu Province(RJFW-40),Jiangsu Province"333 High-level Talent Training Project"(2018III-0121),Technology Innovation Fund of Science and Technology Enterprises in Jiangsu Province(BC2015022),Representative Project of Intangible Cultural Heritage in Pukou District,Nanjing(PKIX-4),and The Construction and Application of Thyroid Disease Differ-entiation and Treatment Rule Mining and Clinical De-cision Support System by Traditional Chinese Medicine Master ZHOU Zhongying(012071003583). （RJFW-40）
