首页|期刊导航|世界急诊医学杂志（英文）|Is rosuvastatin protective against sepsis-associated encephalopathy- A secondary analysis of the SAILS trial
世界急诊医学杂志（英文）2022，Vol.13Issue(5)：367-372,6.DOI:10.5847/wjem.j.1920-8642.2022.072
Is rosuvastatin protective against sepsis-associated encephalopathy- A secondary analysis of the SAILS trial
Is rosuvastatin protective against sepsis-associated encephalopathy? A secondary analysis of the SAILS trial
摘要
Abstract
BACKGROUND: Sepsis is a common cause of death in emergency departments and sepsis-associated encephalopathy (SAE) is a major complication. Rosuvastatin may play a neuroprotective role due to its protective effects on the vascular endothelium and its anti-inflammatory functions. Our study aimed to explore the potential protective function of rosuvastatin against SAE.METHODS: Sepsis patients without any neurological dysfunction on admission were prospectively enrolled in the "Rosuvastatin for Sepsis-Associated Acute Respiratory Distress Syndrome" study (SAILS trial, ClinicalTrials.gov number: NCT00979121). Patients were divided into rosuvastatin and placebo groups. This is a secondary analysis of the SAILS dataset. Baseline characteristics, therapy outcomes, and adverse drug events were compared between groups. RESULTS: A total of 86 patients were eligible for our study. Of these patients, 51 were treated with rosuvastatin. There were significantly fewer cases of SAE in the rosuvastatin group than in the placebo group (32.1％ vs. 57.1％, P=0.028). However, creatine kinase levels were significantly higher in the rosuvastatin group than in the placebo group (233 [22–689] U/L vs. 79 [12–206] U/L, P=0.034). CONCLUSION: Rosuvastatin appears to have a protective role against SAE but may result in a higher incidence of adverse events.关键词
Rosuvastatin calcium/Sepsis-associated encephalopathy/Anti-infl ammatory agents/Sepsis/Adverse reactionsKey words
Rosuvastatin calcium/Sepsis-associated encephalopathy/Anti-infl ammatory agents/Sepsis/Adverse reactions引用本文复制引用
Shi-yuan Yu,Zeng-zheng Ge,Jun Xiang,Yan-xia Gao,Xin Lu,Joseph Harold Walline,Mu-bing Qin,Hua-dong Zhu,Yi Li..Is rosuvastatin protective against sepsis-associated encephalopathy- A secondary analysis of the SAILS trial[J].世界急诊医学杂志（英文）,2022,13(5):367-372,6.基金项目
This research received funding from the CAMS Innovation Fund for Medical Sciences(CIFMS)(2020-I2M-C&T-B-014 （CIFMS）
2021-I2M-1-020). （）
