常州大学学报（自然科学版）2022，Vol.34Issue(5)：72-81,10.DOI:10.3969/j.issn.2095-0411.2022.05.010
迷迭香酸对增强交联透明质酸透皮吸收的作用
Effect of Rosmarinic Acid (RosA) on Enhancing Transdermal Absorption of Crosslinked Hyaluronic Acid (CHA)
摘要
Abstract
To investigate the effects of Rosmarinic acid (RosA) on enhancing the transdermal absorp-tion of cross-linked hyaluronic acid (CHA) ,RosA was obtained and CHA was prepared .The rat-skin transdermal in vitro model was established ,the CHA micro-assay and cytotoxicity model were estab-lished .The stability of HA and CHA at different time-points and temperatures were investigated ,the enhancing effects of RosA and combinations on CHA transdermal were evaluated ,and the cytotoxicity of RosA were investigated .The results showed that 5％ RosA enhanced skin penetration of CHA and was more effective than conventional azone .With the increase of RosA concentrations ,the transder-mal rate of CHA was increased (* * * P=0.001) .RosA (10 mg/mL ) used as the CHA transdermal penetration enhancer did not affect cell grow th in vitro .关键词
迷迭香酸/交联透明质酸/透皮吸收/天然渗透促进剂/细胞毒性Key words
rosmarinic acid/cross-linked hyaluronic acid/transdermal absorption/natural penetration enhancer/cytotoxicity分类
医药卫生引用本文复制引用
刘杰,何浩明,周晓鹰..迷迭香酸对增强交联透明质酸透皮吸收的作用[J].常州大学学报（自然科学版）,2022,34(5):72-81,10.基金项目
海外人才研究实验室启动资助项目(Z391405) （Z391405）
江苏省研究生研究与实践创新资助项目(KYCX19_1777) （KYCX19_1777）
常州大学生命科学研究资助项目(ZMF14020066). （ZMF14020066）
