Discovery of human pancreatic lipase inhibitors from root of Rhodiola crenulata via integrating bioactivity-guided fractionation,chemical profiling and biochemical assay
Li-Juan Ma Tao Lei Guang-Bo Ge Xu-Dong Hou Xiao-Ya Qin Rong-Jing He Hao-Nan Yu Qing Hu Xiao-Qing Guan Shou-Ning Jia Jie Hou
Discovery of human pancreatic lipase inhibitors from root of Rhodiola crenulata via integrating bioactivity-guided fractionation,chemical profiling and biochemical assay
Discovery of human pancreatic lipase inhibitors from root of Rhodiola crenulata via integrating bioactivity-guided fractionation,chemical profiling and biochemical assay
摘要
关键词
Human pancreatic lipase/Rhodiola crenulata/1,2,3,4,6-Penta-O-Galloyl-β-D-glucopyranose/Catechin gallate/Inhibitory mechanismKey words
Human pancreatic lipase/Rhodiola crenulata/1,2,3,4,6-Penta-O-Galloyl-β-D-glucopyranose/Catechin gallate/Inhibitory mechanism引用本文复制引用
Li-Juan Ma,Tao Lei,Guang-Bo Ge,Xu-Dong Hou,Xiao-Ya Qin,Rong-Jing He,Hao-Nan Yu,Qing Hu,Xiao-Qing Guan,Shou-Ning Jia,Jie Hou..Discovery of human pancreatic lipase inhibitors from root of Rhodiola crenulata via integrating bioactivity-guided fractionation,chemical profiling and biochemical assay[J].药物分析学报（英文）,2022,12(4):683-691,9.基金项目
This work was supported by the National Natural Science Foundation of China(Grant Nos.:82160739,81922070,81973286,and 81973393),Sailing Special Project of Shanghai Rising-Star Program(Grant No.:22YF1441500),Program for Innovative Lead-ing Talents of Qinghai Province(2018&2019),Innovation Team and Talents Cultivation Program of National Administration of Tradi-tional Chinese Medicine(Grant No.:ZYYCXTD-D-202004),Shanghai Science and Technology Innovation Action Plans(Grant Nos.:20S21901500 and 20S21900900)supported by the Shanghai Science and Technology Committee,Project of the National Multidisciplinary Innovation Team of Traditional Chinese Medicine supported by the National Administration of Traditional Chinese Medicine,Key R&D and Transformation Science and Technology Cooperation Project of Qinghai Province(Grant No.:2019-HZ-819),and Basic Public Welfare Research Program of Zhejiang Province(Grant No.:LGF22H280012).Furthermore,we are grateful to Zhou Yang(Shanghai Standard Technology Co.,Ltd.,Shanghai,China)for the contribution in the field of MS/MS analysis. （Grant Nos.:82160739,81922070,81973286,and 81973393）
