中南民族大学学报（自然科学版）2022，Vol.41Issue(6)：653-662,10.DOI:10.20056/j.cnki.ZNMDZK.20220603
铜(Ⅱ)介导的芳基丙烯酰胺的级联氰基甲基化合成氰基取代的喹啉-2,4-二酮
Copper(Ⅱ)-mediated cascade cyanomethylation of arylacrylamides to access cyano substituted quinoline-2,4-diones
摘要
Abstract
A practical and efficient Cu-mediated serial radical addition/cyclization reaction of o-cyanoaryl acrylamide with acetonitrile was described. A copper-mediated cascade cyanomethylation of o-cyanoaryl acrylamide with acetonitrile as the radical precursor to access cyano substituted quinoline-2，4-dione was realized. The cyanomethylated quinoline-2，4-diketone products substituted by various substituents could be obtained with high yield under mild conditions，which provided a new method for introducing cyanomethyl group into various quinoline-2，4-diketones products. The method had the advantages of simple operation，mild reaction condition，wide substrate tolerance and great developmental prospect.关键词
铜介导/自由基加成/环化/氰基甲基化/喹啉-2,4-二酮Key words
copper-mediated/radical addition/cyclization/cyanomethylation/quinoline-2,4-dione分类
化学化工引用本文复制引用
李莉,连国,路明坤,孙焕,刘吉开..铜(Ⅱ)介导的芳基丙烯酰胺的级联氰基甲基化合成氰基取代的喹啉-2,4-二酮 [J].中南民族大学学报（自然科学版）,2022,41(6):653-662,10.基金项目
国家自然科学基金资助项目（81803395）；湖北省自然科学基金资助项目（2018CFB222）；中央高校基本科研业务费专项资金资助项目（CZY20023）；中南民族大学大学生创新创业培训计划资助项目 （）
