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Integration of network pharmacology with experimental verification reveals the hypoglycemic mechanism of coptisine in Jinqi Jiangtang tablets: inhibition of the FoxO1 signaling pathway and hepatic gluconeogenesis

Hang Gong Yu-Cai Chen Jia-Qi Xie Yi-Hong Li Li-Dan Cui Hong-Tao Jin Can Wang

传统医学研究(英文版)2023,Vol.8Issue(3):51-61,11.
传统医学研究(英文版)2023,Vol.8Issue(3):51-61,11.

Integration of network pharmacology with experimental verification reveals the hypoglycemic mechanism of coptisine in Jinqi Jiangtang tablets: inhibition of the FoxO1 signaling pathway and hepatic gluconeogenesis

Integration of network pharmacology with experimental verification reveals the hypoglycemic mechanism of coptisine in Jinqi Jiangtang tablets: inhibition of the FoxO1 signaling pathway and hepatic gluconeogenesis

Hang Gong 1Yu-Cai Chen 2Jia-Qi Xie 1Yi-Hong Li 1Li-Dan Cui 1Hong-Tao Jin 1Can Wang2

作者信息

  • 1. School of Chinese Materia Medica/School of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing 100029,China
  • 2. State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China
  • 折叠

摘要

关键词

Jinqi Jiangtang tablets/FoxO1/gluconeogenesis/type 2 diabetes mellitus/network pharmacology

Key words

Jinqi Jiangtang tablets/FoxO1/gluconeogenesis/type 2 diabetes mellitus/network pharmacology

引用本文复制引用

Hang Gong,Yu-Cai Chen,Jia-Qi Xie,Yi-Hong Li,Li-Dan Cui,Hong-Tao Jin,Can Wang..Integration of network pharmacology with experimental verification reveals the hypoglycemic mechanism of coptisine in Jinqi Jiangtang tablets: inhibition of the FoxO1 signaling pathway and hepatic gluconeogenesis[J].传统医学研究(英文版),2023,8(3):51-61,11.

基金项目

This study was supported by the Fundamental Research Funds for the Central Universities(grant number:2021-JYB-XJSJJ-003),the Open Project of State Key Laboratory of Bioactive Substance and Function of Natural Medicines(grant number:GTZK202108),Chinese Society of Toxicology(grant number:CST2021CT101)and Discipline Construction Project of Peking Union Medical College(grant number:201920200801).We thank International Science Editing(http://www.internationalscienceediting.com)for editing this manuscript. (grant number:2021-JYB-XJSJJ-003)

传统医学研究(英文版)

2413-3973

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