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LC-MS/MS method for the quantitation of serum tocilizumab in rheumatoid arthritis patients using rapid tryptic digestion without IgG purification

Takashi Mochizuki Kaito Shibata Takafumi Naito Kumiko Shimoyama Noriyoshi Ogawa Masato Maekawa Junichi Kawakami

药物分析学报：英文版2022，Vol.12Issue(6)：P.852-859,8.

药物分析学报：英文版2022，Vol.12Issue(6)：P.852-859,8.DOI:10.1016/j.jpha.2022.08.003

LC-MS/MS method for the quantitation of serum tocilizumab in rheumatoid arthritis patients using rapid tryptic digestion without IgG purification

Takashi Mochizuki ¹Kaito Shibata ²Takafumi Naito ²Kumiko Shimoyama ³Noriyoshi Ogawa ³Masato Maekawa ⁴Junichi Kawakami¹

作者信息

1. Department of Hospital Pharmacy,Hamamatsu University School of Medicine,Hamamatsu,431-3192,Japan
2. Department of Hospital Pharmacy,Hamamatsu University School of Medicine,Hamamatsu,431-3192,Japan Department of Pharmacy,Shinshu University Hospital,Matsumoto,Nagano,390-8621,Japan
3. Third Division,Department of Internal Medicine,Hamamatsu University School of Medicine,Hamamatsu,431-3192,Japan
4. Department of Laboratory Medicine,Hamamatsu University School of Medicine,Hamamatsu,431-3192,Japan
折叠

摘要

关键词

Tocilizumab/LC-MS/MS/Immobilized trypsin/IgG purification/Proteomics/Rheumatoid arthritis

分类

医药卫生

引用本文复制引用

Takashi Mochizuki,Kaito Shibata,Takafumi Naito,Kumiko Shimoyama,Noriyoshi Ogawa,Masato Maekawa,Junichi Kawakami..LC-MS/MS method for the quantitation of serum tocilizumab in rheumatoid arthritis patients using rapid tryptic digestion without IgG purification[J].药物分析学报：英文版,2022,12(6):P.852-859,8.

基金项目

supported by the Japan Society for the Promotion of Science KAKENHI(Grant No.:JP19H00349). （Grant No.:JP19H00349）

药物分析学报：英文版

OACSCDSCI

ISSN：2095-1779

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