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Discovery of pulmonary fibrosis inhibitor targeting TGF-b RI in Polygonum cuspidatum by high resolution mass spectrometry with in silico strategy

Huarong Xu Jiameng Qu Jian Wang Kefei Han Qing Li Wenchuan Bi Ran Liu

药物分析学报：英文版2022，Vol.12Issue(6)：P.860-868,9.

药物分析学报：英文版2022，Vol.12Issue(6)：P.860-868,9.DOI:10.1016/j.jpha.2020.05.007

Discovery of pulmonary fibrosis inhibitor targeting TGF-b RI in Polygonum cuspidatum by high resolution mass spectrometry with in silico strategy

Huarong Xu ¹Jiameng Qu ²Jian Wang ³Kefei Han ²Qing Li ¹Wenchuan Bi ⁴Ran Liu¹

作者信息

1. National and Local Joint Engineering Laboratory for Key Technology of Chinese Material Medica Quality Control,School of Pharmacy,Shenyang Pharmaceutical University,Shenyang,110016,China
2. National and Local Joint Engineering Laboratory for Key Technology of Chinese Material Medica Quality Control,School of Pharmacy,Shenyang Pharmaceutical University,Shenyang,110016,China School of Traditional Chinese Material Medica,Shenyang Pharmaceutical University,Shenyang,110016,China
3. Key Laboratory of Structure-Based Drug Design&Discovery of Ministry of Education,Shenyang Pharmaceutical University,Shenyang,110016,China
4. Health Science Center Department of Pharmacy,Shenzhen University,Shenzhen,Guangdong,518118,China
折叠

摘要

关键词

Polygonum cuspidatum/Pulmonary fibrosis/TGF-βreceptor type-I/Resveratrol/High resolution mass spectrometry/Molecular docking

分类

医药卫生

引用本文复制引用

Huarong Xu,Jiameng Qu,Jian Wang,Kefei Han,Qing Li,Wenchuan Bi,Ran Liu..Discovery of pulmonary fibrosis inhibitor targeting TGF-b RI in Polygonum cuspidatum by high resolution mass spectrometry with in silico strategy[J].药物分析学报：英文版,2022,12(6):P.860-868,9.

基金项目

supported by the National Natural Science Foundation of China(Grant Nos.:81703463 and 81603277) （Grant Nos.:81703463 and 81603277）

the National Key R&D Program of China(Grant No.:U1508220) （Grant No.:U1508220）

the Liaoning Distinguished Professor Project for Qing Li,and the Doctoral Scientific Research Foundation of Liaoning Province(Grant No.:20170520199). （Grant No.:20170520199）

药物分析学报：英文版

OACSCDSCI

ISSN：2095-1779

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