Discovery of pulmonary fibrosis inhibitor targeting TGF-b RI in Polygonum cuspidatum by high resolution mass spectrometry with in silico strategyOACSCDSCI
Pulmonary fibrosis(PF)is an irreversible lung disease that is characterized by excessive scar tissue with a poor median survival rate of 2-3 years.The inhibition of transforming growth factor-β receptor type-I(TGF-β RI)by an …查看全部>>
Huarong Xu;Jiameng Qu;Jian Wang;Kefei Han;Qing Li;Wenchuan Bi;Ran Liu
National and Local Joint Engineering Laboratory for Key Technology of Chinese Material Medica Quality Control,School of Pharmacy,Shenyang Pharmaceutical University,Shenyang,110016,ChinaNational and Local Joint Engineering Laboratory for Key Technology of Chinese Material Medica Quality Control,School of Pharmacy,Shenyang Pharmaceutical University,Shenyang,110016,China School of Traditional Chinese Material Medica,Shenyang Pharmaceutical University,Shenyang,110016,ChinaKey Laboratory of Structure-Based Drug Design&Discovery of Ministry of Education,Shenyang Pharmaceutical University,Shenyang,110016,ChinaNational and Local Joint Engineering Laboratory for Key Technology of Chinese Material Medica Quality Control,School of Pharmacy,Shenyang Pharmaceutical University,Shenyang,110016,China School of Traditional Chinese Material Medica,Shenyang Pharmaceutical University,Shenyang,110016,ChinaNational and Local Joint Engineering Laboratory for Key Technology of Chinese Material Medica Quality Control,School of Pharmacy,Shenyang Pharmaceutical University,Shenyang,110016,ChinaHealth Science Center Department of Pharmacy,Shenzhen University,Shenzhen,Guangdong,518118,ChinaNational and Local Joint Engineering Laboratory for Key Technology of Chinese Material Medica Quality Control,School of Pharmacy,Shenyang Pharmaceutical University,Shenyang,110016,China
药学
Polygonum cuspidatumPulmonary fibrosisTGF-βreceptor type-IResveratrolHigh resolution mass spectrometryMolecular docking
《药物分析学报：英文版》 2022 (6)
P.860-868,9
supported by the National Natural Science Foundation of China(Grant Nos.:81703463 and 81603277)the National Key R&D Program of China(Grant No.:U1508220)the Liaoning Distinguished Professor Project for Qing Li,and the Doctoral Scientific Research Foundation of Liaoning Province(Grant No.:20170520199).
评论