空军军医大学学报2023，Vol.44Issue(2)：105-110,6.DOI:10.13276/j.issn.2097-1656.2023.02.002
焦虑和抑郁导致偏头痛患者fALFF改变:一项fMRI横断面研究
Anxiety and depression lead to fALFF changes in migraine patients:an fMRI cross-sectional study
摘要
Abstract
Objective To investigate the effects of anxiety and depression on brain functional alterations in migraine patients.Methods Resting-state functional magnetic resonance imaging data were used to analyze the changes in fractional amplitude of low-frequency fluctuation(fALFF)in 46 patients with migraine without aura and 34 age-and gender-matched healthy controls.Pearson correlation analysis was used to explore the relationship between changes in fALFF and clinical characteristics.Results The fALFF value of the posterior lobe of left cerebellum increased in migraine patients with or without anxiety and depression.In patients with migraine without anxiety and depression,decreased fALFF values were found in the thalamus,temporal lobe,and frontal lobe.In patients with migraine with anxiety and depression,fALFF value in cerebellum was negatively correlated with the Montreal Cognitive Assessment scores.Conclusion The posterior lobe of left cerebellum is a continuously activated region in migraine patients.This region may be a target region for further understanding the mechanism of migraine attack.关键词
偏头痛/磁共振成像/分数低频振幅/抑郁症Key words
migraine/magnetic resonance imaging/fractional amplitude of low-frequency fluctuation/depression分类
医药卫生引用本文复制引用
陈柱鸿,徐强,杨冠,张驰,孙婧婷,尚宇轩,胡博,王文..焦虑和抑郁导致偏头痛患者fALFF改变:一项fMRI横断面研究[J].空军军医大学学报,2023,44(2):105-110,6.基金项目
National Natural Science Foundation of China(81571656) （81571656）
Military Medical Innovation Program(18CXZ016) （18CXZ016）
