Epigenetic drug library screening reveals targeting DOT1L abrogates NAD+synthesis by reprogramming H3K79 methylation in uveal melanoma
Epigenetic drug library screening reveals targeting DOT1L abrogates NAD+synthesis by reprogramming H3K79 methylation in uveal melanoma
摘要
关键词
Histone methylation/Metabolic reprogramming/Uveal melanoma/Transcriptional addictionKey words
Histone methylation/Metabolic reprogramming/Uveal melanoma/Transcriptional addiction引用本文复制引用
Xiang Gu,Yu Hua,Jie Yu,Ludi Yang,Shengfang Ge,Renbing Jia,Peiwei Chai,Ai Zhuang,Xianqun Fan..Epigenetic drug library screening reveals targeting DOT1L abrogates NAD+synthesis by reprogramming H3K79 methylation in uveal melanoma[J].药物分析学报（英文）,2023,13(1):24-38,15.基金项目
This work was supported by grants from Shanghai Key Clinical Specialty,Shanghai Eye Disease Research Center(Grant No.:2022ZZ01003 to Xianqun Fan),the National Key Research and Development Plan(Grant No.:2018YFC1106100 to Xianqun Fan),the National Natural Science Foundation of China(Grant Nos.:12275178 to Shengfang Ge and 82103240 to Peiwei Chai),Innova-tive Research Team of High-level Local Universities in Shanghai(Grant Nos.:SHSMU-ZDCX20210902 to Renbing Jia and SHSMU-ZDCX20210900 to Xianqun Fan),the Science and Technology Commission of Shanghai(Grant No.:19JC1410200 to Xianqun Fan),and Cross-disciplinary Research Fund of Shanghai Ninth People's Hospital,Shanghai Jiao Tong university School of Medicine(Grant No.:JYJC202210 to Ai Zhuang). （Grant No.:2022ZZ01003 to Xianqun Fan）
