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Skeletal phenotypes in secreted frizzled-related protein 4 gene knockout mice mimic skeletal architectural abnormalities in subjects with Pyle's disease from SFRP4 mutations

Robert Brommage Jeff Liu David R.Powell

骨研究（英文版）2023，Vol.11Issue(1)：193-200,8.
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骨研究（英文版）2023，Vol.11Issue(1)：193-200,8.

Skeletal phenotypes in secreted frizzled-related protein 4 gene knockout mice mimic skeletal architectural abnormalities in subjects with Pyle's disease from SFRP4 mutations

Skeletal phenotypes in secreted frizzled-related protein 4 gene knockout mice mimic skeletal architectural abnormalities in subjects with Pyle's disease from SFRP4 mutations

Robert Brommage 1Jeff Liu 2David R.Powell1

作者信息

  • 1. Department of Metabolism Research,Lexicon Pharmaceuticals,The Woodlands,TX 77381,USA
  • 2. Present address:BoneGenomics,The Woodlands,TX,USA
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摘要

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Robert Brommage,Jeff Liu,David R.Powell..Skeletal phenotypes in secreted frizzled-related protein 4 gene knockout mice mimic skeletal architectural abnormalities in subjects with Pyle's disease from SFRP4 mutations[J].骨研究（英文版）,2023,11(1):193-200,8.

基金项目

All studies were supported by Lexicon Pharmaceuticals.Wendy Xiong sectioned plastic-embedded femurs and Andrea Y.Thompson examined the cortical bone sections by fluorescent microscopy.Victor Shen and Vonn Wright of Numira Biosciences performed the bone strength measurements.Hiroaki Saito,Francesca Gori,Eric Hesse and Roland Baron provided insights from their Sfrp4 KO mouse studies. （）

骨研究（英文版）

OACSCDMEDLINE

2095-4700

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