物理学进展2023，Vol.43Issue(2)：41-55,15.DOI:10.13725/j.cnki.pip.2023.02.002
基于活性网络模型的细胞组织模拟
Cell Tissue Simulations Based on Active Network Models
摘要
Abstract
In the last decade, motivated by advances in cell biology, theoretical studies of the cell tissue as active matter have emerged as a new area in soft matter physics. This article reviews recent theoretical progresses based on the active network (AN) model of cell tissue. In the mesoscopic scale, the non-equilibrium dynamics of cell tissue is mainly driven by the self-propulsion of cells and non-propulsion activities, like active contractility or cellular tension/volume oscillation. AN models of self-propelled cells can reproduce complex dynamics of cell tissue in vivio, such as activity/adhesion driven solid-liquid transition, flocking and active turbulence. The AN model incorporating cellular tension fluctuation can also simulate the cell volume oscillation waves in embryo of Drosophila, and predict the fluctuation-driven solid-liquid transition of cell tissue. The structural phase transition and density fluctuation of cell tissue were also studied by using AN models, which deepens our understanding of this unique non-equilibrium soft matter system.关键词
细胞组织/活性网络模型/动力学与转变Key words
cell tissue/active network models/dynamic and transition分类
数理科学引用本文复制引用
李诸钦,雷群利,马余强..基于活性网络模型的细胞组织模拟[J].物理学进展,2023,43(2):41-55,15.基金项目
This work is supported by the National Natu-ral Science Foundation of China(No.11974175,No.12174184,No.12247102,No.12275127). （No.11974175,No.12174184,No.12247102,No.12275127）
