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Celastrol targeting Nedd4 reduces Nrf2-mediated oxidative stress in astrocytes after ischemic stroke

Zexuan Hong Jun Cao Dandan Liu Maozhu Liu Mengyuan Chen Fanning Zeng Zaisheng Qin Jigang Wang Tao Tao

药物分析学报（英文）2023，Vol.13Issue(2)：156-169,14.

Celastrol targeting Nedd4 reduces Nrf2-mediated oxidative stress in astrocytes after ischemic stroke

Zexuan Hong ¹Jun Cao ²Dandan Liu ³Maozhu Liu ⁴Mengyuan Chen ⁵Fanning Zeng ²Zaisheng Qin ²Jigang Wang ³Tao Tao⁶

作者信息

1. Department of Anesthesiology,Nanfang Hospital,Southern Medical University,Guangzhou,510515,China||Department of Anesthesiology,Central People's Hospital of Zhanjiang,Zhanjiang,Guangdong,524045,China
2. Department of Anesthesiology,Nanfang Hospital,Southern Medical University,Guangzhou,510515,China
3. Artemisinin Research Center,Institute of Chinese Materia Medico,China Academy of Chinese Medical Sciences,Beijing,100700,China
4. Department of Pharmacy,West China Hospital,Sichuan University,Chengdu,610000,China
5. Department of Pharmacy,Xi'an Daxing Hospital,Xi'an,710000,China
6. Department of Anesthesiology,Central People's Hospital of Zhanjiang,Zhanjiang,Guangdong,524045,China
折叠

摘要

关键词

Celastrol/Cerebral ischemia/Reperfusion injury/Oxidative stress/Nedd4/Nrf2/Ubiquitylation

Key words

Celastrol/Cerebral ischemia/Reperfusion injury/Oxidative stress/Nedd4/Nrf2/Ubiquitylation

引用本文复制引用

Zexuan Hong,Jun Cao,Dandan Liu,Maozhu Liu,Mengyuan Chen,Fanning Zeng,Zaisheng Qin,Jigang Wang,Tao Tao..Celastrol targeting Nedd4 reduces Nrf2-mediated oxidative stress in astrocytes after ischemic stroke[J].药物分析学报（英文）,2023,13(2):156-169,14.

基金项目

This work was funded by the National Natural Science Foun-dation of China(Grant No.:81973305),the Science and Technology Planning Project of Guangzhou,China(Grant No.:201904010487),the Natural Science Foundation of Guangdong Province,China(Grant No.:2021A1515010897),and the Discipline Construction Fund of Central People's Hospital of Zhanjiang(Grant Nos.:2020A01 and 2020A02).We also would like to thank Dr.Lei Li for her kind assistance in experiment implementation. （Grant No.:81973305）

药物分析学报（英文）

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ISSN：2095-1779

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