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Anti-diabetic potential of apigenin,luteolin,and baicalein via partially activating PI3K/Akt/GLUT-4 signaling pathways in insulin-resistant HepG2 cells

Lingchao Miao Haolin Zhang Meng Sam Cheong Ruting Zhong Paula Garcia-Oliveira Miguel A.Prieto Ka-Wing Cheng Mingfu Wang Hui Cao Shaoping Nie Jesus Simal-Gandara Wai San Cheang Jianbo Xiao

食品科学与人类健康(英文)2023，Vol.12Issue(6)：P.1991-2000,10.

食品科学与人类健康(英文)2023，Vol.12Issue(6)：P.1991-2000,10.DOI:10.1016/j.fshw.2023.03.021

Anti-diabetic potential of apigenin,luteolin,and baicalein via partially activating PI3K/Akt/GLUT-4 signaling pathways in insulin-resistant HepG2 cells

Lingchao Miao ¹Haolin Zhang ¹Meng Sam Cheong ¹Ruting Zhong ¹Paula Garcia-Oliveira ²Miguel A.Prieto ²Ka-Wing Cheng ³Mingfu Wang ⁴Hui Cao ⁵Shaoping Nie ⁶Jesus Simal-Gandara ²Wai San Cheang ¹Jianbo Xiao⁷

作者信息

1. Institute of Chinese Medical Sciences,University of Macao,Macao 999078,China
2. Department of Analytical Chemistry and Food Science,Faculty of Food Science and Technology,University of Vigo-Ourense Campus,Ourense E-32004,Spain
3. Institute for Advanced Study,Shenzhen University,Shenzhen 508060,China
4. Institute for Advanced Study,Shenzhen University,Shenzhen 508060,China School of Biological Sciences,The University of Hong Kong,Hong Kong 999077,China
5. Department of Analytical Chemistry and Food Science,Faculty of Food Science and Technology,University of Vigo-Ourense Campus,Ourense E-32004,Spain College of Food Science and Technology,Guangdong Ocean University,Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety,Guangdong Province Engineering Laboratory for Marine Biological Products,Guangdong Provincial Engineering Technology Research Center of Seafood,Key Laboratory of Advanced Processing of Aquatic Product of Guangdong Higher Education Institution,Zhanjiang 524088,China
6. State Key Laboratory of Food Science and Technology,China-Canada Joint Lab of Food Science and Technology(Nanchang),Nanchang University,Nanchang 330047,China
7. Department of Analytical Chemistry and Food Science,Faculty of Food Science and Technology,University of Vigo-Ourense Campus,Ourense E-32004,Spain International Research Center for Food Nutrition and Safety,Jiangsu University,Zhenjiang 212013,China
折叠

摘要

关键词

Apigenin/Luteolin/Baicalein/Insulin-resistant HepG2 cells/Signaling pathway/Reactive oxygen species(ROS)/Advanced glycation end-products(AGEs)/Glycogen synthase kinase(GSK-3β)/Glucose transporter protein 4(GLUT4)

分类

轻工纺织

引用本文复制引用

Lingchao Miao,Haolin Zhang,Meng Sam Cheong,Ruting Zhong,Paula Garcia-Oliveira,Miguel A.Prieto,Ka-Wing Cheng,Mingfu Wang,Hui Cao,Shaoping Nie,Jesus Simal-Gandara,Wai San Cheang,Jianbo Xiao..Anti-diabetic potential of apigenin,luteolin,and baicalein via partially activating PI3K/Akt/GLUT-4 signaling pathways in insulin-resistant HepG2 cells[J].食品科学与人类健康(英文),2023,12(6):P.1991-2000,10.

基金项目

supported by National Natural Science Foundation of China(32072212) （32072212）

Multi-Year Research Grant of University of Macao(MYRG2018-00169-ICMS) （MYRG2018-00169-ICMS）

Science and Technology Development Fund of Macao(FDCT)(0098/2020/A) （FDCT）

MICINN supporting the Ramón y Cajal grant for M.A.Prieto(RYC-201722891) （RYC-201722891）

Jianbo Xiao(RYC2020-030365-I) （RYC2020-030365-I）

Xunta de Galicia supporting the Axudas Conecta Peme,the IN852A 2018/58 Neuro Food Project,the program EXCELENCIA-ED431F 2020/12 （）

the pre-doctoral grants of P.García-Oliveira(ED481A-2019/295) （ED481A-2019/295）

to Ibero-American Program on Science and Technology(CYTED-AQUA-CIBUS,P317RT0003). （CYTED-AQUA-CIBUS,P317RT0003）

食品科学与人类健康(英文)

OACSCD

ISSN：2097-0765

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