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Spatiotemporal pharmacometabolomics based on ambient mass spectrometry imaging to evaluate the metabolism and hepatotoxicity of amiodarone in HepG2 spheroids

Limei Li Qingce Zang Xinzhu Li Ying Zhu Shanjing Wen Jiuming He Ruiping Zhang Zeper Abliz

药物分析学报（英文）2023，Vol.13Issue(5)：483-493,11.

Spatiotemporal pharmacometabolomics based on ambient mass spectrometry imaging to evaluate the metabolism and hepatotoxicity of amiodarone in HepG2 spheroids

Limei Li ¹Qingce Zang ¹Xinzhu Li ¹Ying Zhu ¹Shanjing Wen ¹Jiuming He ¹Ruiping Zhang ¹Zeper Abliz²

作者信息

1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,100050,China
2. State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,100050,China||Key Laboratory of Mass Spectrometry Imaging and Metabolomics(Minzu University of China),National Ethnic Affairs Commission,Beijing,100081,China||Center for Imaging and Systems Biology,College of Life and Environmental Sciences,Minzu University of China,Beijing,100081,China
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摘要

关键词

Mass spectrometry imaging/HepG2 spheroids/Hepatotoxicity/Drug metabolism/Amiodarone

Key words

Mass spectrometry imaging/HepG2 spheroids/Hepatotoxicity/Drug metabolism/Amiodarone

引用本文复制引用

Limei Li,Qingce Zang,Xinzhu Li,Ying Zhu,Shanjing Wen,Jiuming He,Ruiping Zhang,Zeper Abliz..Spatiotemporal pharmacometabolomics based on ambient mass spectrometry imaging to evaluate the metabolism and hepatotoxicity of amiodarone in HepG2 spheroids[J].药物分析学报（英文）,2023,13(5):483-493,11.

基金项目

This research was funded by the National Natural Science Foundation of China(Grant No.:21874156),and the Chinese Academy of Medical Science(CAMS)Innovation Fund for Medical Sciences(Grant No.:2021-1-I2M-028). （Grant No.:21874156）

药物分析学报（英文）

OACSCD

ISSN：2095-1779

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