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RANKL+ senescent cells under mechanical stress:a therapeutic target for orthodontic root resorption using senolytics

Yue Zhou Naoyuki Matsumoto Aki Nishiura Hidetoshi Morikuni Wenqi Deng Toru Tsujibayashi Yoshihiro Momota Yuki Azetsu Masamichi Takami Yoshitomo Honda

国际口腔科学杂志（英文版）2023，Vol.15Issue(2)：278-290,13.
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国际口腔科学杂志（英文版）2023，Vol.15Issue(2)：278-290,13.DOI:10.1038/s41368-023-00228-1

RANKL+ senescent cells under mechanical stress:a therapeutic target for orthodontic root resorption using senolytics

RANKL+ senescent cells under mechanical stress:a therapeutic target for orthodontic root resorption using senolytics

Yue Zhou 1Naoyuki Matsumoto 1Aki Nishiura 1Hidetoshi Morikuni 1Wenqi Deng 1Toru Tsujibayashi 2Yoshihiro Momota 3Yuki Azetsu 4Masamichi Takami 4Yoshitomo Honda5

作者信息

  • 1. Department of Orthodontics,Osaka Dental University,8-1 Kuzuhahanazonocho,Hirakata,Osaka,Japan
  • 2. Department of Physics,Osaka Dental University,8-1 Kuzuhahanazonocho,Hirakata,Osaka,Japan
  • 3. Department of Anesthesiology,Osaka Dental University,8-1 Kuzuhahanazonocho,Hirakata,Osaka,Japan
  • 4. Department of Pharmacology,Showa University School of Dentistry,1-5-8 Hatanodai,Shinagawaku,Tokyo,Japan
  • 5. Department of Oral Anatomy,Osaka Dental University,8-1 Kuzuhahanazonocho,Hirakata,Osaka,Japan
  • 折叠

摘要

引用本文复制引用

Yue Zhou,Naoyuki Matsumoto,Aki Nishiura,Hidetoshi Morikuni,Wenqi Deng,Toru Tsujibayashi,Yoshihiro Momota,Yuki Azetsu,Masamichi Takami,Yoshitomo Honda..RANKL+ senescent cells under mechanical stress:a therapeutic target for orthodontic root resorption using senolytics[J].国际口腔科学杂志（英文版）,2023,15(2):278-290,13.

基金项目

We thank Ye Zhang,Yuzhu Sun(Department of Biomaterials,Osaka Dental University),Jianxin Zhao,Yoshitsugu Nakamoto,Yosuke Miyaji,Hiroshi Matoba(Department of Orthodontics,Osaka Dental University)for advising the animal experiments,and Keita Yoshida(Department of Anesthesiology,Osaka Dental University)and Yuya Hirai(Department of Biology,Osaka Dental University)for support in the Immunofluorescence staining.This work was supported by JST,CREST Grant Number JPMJCR22L5,Japan. （Department of Biomaterials,Osaka Dental University）

国际口腔科学杂志（英文版）

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