日用化学工业（中英文）2023，Vol.53Issue(7)：757-764,8.DOI:10.3969/j.issn.2097-2806.2023.07.004
植物复合舒缓剂(CAP)对外源性皮肤刺激的保护作用
The protection mechanism of multi-herb extract CAP against exogenous cutaneous stimulation
周利丹 1卢伊娜 1杨继峰 1施雪梅 1熊玥 1张磊1
作者信息
- 1. 上海珈凯生物股份有限公司,上海 201506
- 折叠
摘要
Abstract
The skin contains a myriad of immune cells and acts as the first line of defense system against the external environment both as a physical and immune barrier.The cutaneous immune system begins to work even before birth and continuously evolves throughout the lifetime to achieve optimal function by adapting to environmental cues.This study explored the potential mechanism of multi-herb extract CAP against exogenous cutaneous stimulation and discussed the key modulators that drove productive immune responses in skin epidermis and dermal layer immune cells,including keratinocytes,monocytes,and mast cells.Also,a three-dimensional(3D)reconstructed human epidermis model(EpiKutis)was used to perform relevant assays.CAP reduced the expressions of thymic stromal lymphopoietin(TSLP),interleukin-8(IL-8),prostaglandin E2(PGE-2),interleukin-6(IL-6),and tumor necrosis factor-alpha(TNF-α)that were increased by exogenous stimuli in keratinocytes,3D EpiKutis,THP-1-derived cells or mast cells.Furthermore,CAP dose-dependently promoted filaggrin level which was decreased by poly(I:C)and LPS induction.These results suggest that CAP might have regulatory functions on keratinocytes,monocytes,and mast cells,which play important roles on the sense,initial and primary stages of the skin inflammatory reactions,respectively.关键词
植物复合舒缓剂/胸腺基质淋巴细胞生成素/皮肤刺激性反应/角质形成细胞/单核细胞/肥大细胞Key words
multi-herb extract CAP/thymic stromal lymphopoietin/skin inflammatory reactions/keratinocytes/monocytes/mast cells分类
化学化工引用本文复制引用
周利丹,卢伊娜,杨继峰,施雪梅,熊玥,张磊..植物复合舒缓剂(CAP)对外源性皮肤刺激的保护作用[J].日用化学工业（中英文）,2023,53(7):757-764,8.
