物理化学学报2023，Vol.39Issue(7)：100-109,10.DOI:10.3866/PKU.WHXB202211043
银纳米粒子修饰的二维金属-有机框架纳米片用于光热增强银离子释放抗菌
Silver Nanoparticle-Modified 2D MOF Nanosheets for Photothermally Enhanced Silver Ion Release Antibacterial Treatment
摘要
Abstract
Recently,two-dimensional(2D)metal-organic framework(MOF)nanosheet-based composites have been extensively investigated as promising materials for biomedical applications,including antibacterial applications.This study reports the synthesis of silver nanoparticle(Ag NP)-modified 2D Zr-ferrocene-MOF(MOF-Ag)nanosheets by growing Ag NPs on 2D MOF nanosheets via light irradiation-induced reduction for photothermally enhanced silver ion(Ag+)release antibacterial treatment.The MOF nanosheets were synthesized by a hydrothermal method followed by ultrasonic treatment.Subsequently,Ag NPs were grown on the MOF nanosheets to obtain MOF-Ag nanosheets by in situ light irradiation-induced reduction.Various characterization results,including transmission electron microscopy(TEM),X-ray photoelectron spectroscopy(XPS),and inductively coupled plasma-mass spectrometry(ICP-MS),showed that Ag NPs were successfully loaded onto the surface of the MOF nanosheets.Fourier transform infrared(FTIR)spectroscopy further confirmed the successful modification of the MOF-Ag surface with polyvinylpyrrolidone(PVP).The modification with of PVP not only enhanced the stability of MOF-Ag in solution,but also enhanced its biocompatibility.Under 808 nm near-infrared laser(NIR)irradiation,the MOF nanosheets exhibited good photothermal properties and photothermal conversion efficiency.The temperature increase induced by the photothermal effect accelerates the oxidation of Ag NPs to Ag+,and thus MOF-Ag continuously releases silver ions to kill bacteria.It was concluded that PVP-functionalized MOF-Ag(PVP@MOF-Ag)nanosheets have good antibacterial properties using experimental analyses such as bacterial growth curves,relative number of colonies,and morphological changes of bacteria.PVP@MOF-Ag nanosheets not only kills S.aureus but also inhibits E.coli growth more efficiently,exhibiting broad-spectrum bactericidal properties.Additionally,the good photothermal performance of the 2D MOF nanosheets enhanced Ag+release and cell membrane permeability.Ag NPs release Ag+in solution via an oxidation mechanism,and the released Ag+is more likely to enter the bacteria via the cell membrane under light conditions.In bacteria,Ag+induces the generation of endogenous reactive oxygen species to trigger oxidative stress,thus realizing efficient antibacterial performance.Based on the above-mentioned antibacterial mechanism and good in vitro antibacterial properties,the PVP@MOF-Ag nanosheets were used for wound healing in mice.By developing a mouse wound healing model and treating mouse wounds within a week,it was observed that PVP@MOF-Ag nanosheets have a good therapeutic effect and good biosafety during treatment.These results demonstrate that PVP@MOF-Ag nanosheets are an efficient platform for photothermally enhanced Ag+release antibacterial therapy and wound healing.关键词
二维金属-有机框架材料/二维复合材料/银离子释放/光热治疗/抗菌Key words
2D MOFs/2D composites/Ag+ release/Photothermal therapy/Antibacterial分类
化学引用本文复制引用
赵信硕,谭超良,邱海燕,邵依,王攀捷,余石龙,李海,周郁斌,周战,马录芳..银纳米粒子修饰的二维金属-有机框架纳米片用于光热增强银离子释放抗菌[J].物理化学学报,2023,39(7):100-109,10.基金项目
The project was supported by the National Natural Science Foundation of China(52102348,22171123,22005259),the Science and Technology Innovation Talent Program of University in Henan Province(23HASTIT016),the Guangdong Basic and Applied Basic Research Foundation(2019A1515111112,2021A1515011831)and the Special Projects in Key Areas for General Colleges and Universities of Guangdong Province(2021ZDZX2061)and the Start-Up Grant from City University of Hong Kong(9610495).国家自然科学基金(52102348,22171123,22005259),河南省高校科技创新人才计划(23HASTIT016),广东省基础与应用基础研究基金(2019A1515111112,2021A1515011831),广东省普通高校重点领域专项(2021ZDZX2061)及香港城市大学启动基金(9610495)资助项目 （52102348,22171123,22005259）
