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Inhibition of histone methyltransferase PRMT5 attenuates cisplatin-induced hearing loss through the PI3K/Akt-mediated mitochondrial apoptotic pathway

Zhiwei Zheng Benyu Nan Chang Liu Dongmei Tang Wen Li Liping Zhao Guohui Nie Yingzi He

药物分析学报（英文）2023，Vol.13Issue(6)：590-602,13.
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药物分析学报（英文）2023，Vol.13Issue(6)：590-602,13.DOI:10.1016/j.jpha.2023.04.014

Inhibition of histone methyltransferase PRMT5 attenuates cisplatin-induced hearing loss through the PI3K/Akt-mediated mitochondrial apoptotic pathway

Inhibition of histone methyltransferase PRMT5 attenuates cisplatin-induced hearing loss through the PI3K/Akt-mediated mitochondrial apoptotic pathway

Zhiwei Zheng 1Benyu Nan 2Chang Liu 3Dongmei Tang 1Wen Li 1Liping Zhao 1Guohui Nie 4Yingzi He1

作者信息

  • 1. ENT Institute and Department of Otorhinolaryngology,Eye & ENT Hospital,State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science,NHC Key Laboratory of Hearing Medicine(Fudan University),Fudan University,Shanghai,200031,China
  • 2. Department of Otorhinolaryngology-Head and Neck Surgery,The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Wenzhou,325000,Zhejiang,China
  • 3. Department of Otolaryngology-Head and Neck Surgery,The Third Affiliated Hospital of Sun Yat-Sen University,Guangzhou,510630,China
  • 4. Department of Otolaryngology,Shenzhen Institute of Translational Medicine,Shenzhen Second People's Hospital,The First Affiliated Hospital of Shenzhen University,Shenzhen,518035,Guangdong,China
  • 折叠

摘要

关键词

Protein arginine methyltransferase 5(PRMT5)/LLY-283/Cisplatin/Hearing loss/Hair cell/Spiral ganglion neuron

Key words

Protein arginine methyltransferase 5(PRMT5)/LLY-283/Cisplatin/Hearing loss/Hair cell/Spiral ganglion neuron

引用本文复制引用

Zhiwei Zheng,Benyu Nan,Chang Liu,Dongmei Tang,Wen Li,Liping Zhao,Guohui Nie,Yingzi He..Inhibition of histone methyltransferase PRMT5 attenuates cisplatin-induced hearing loss through the PI3K/Akt-mediated mitochondrial apoptotic pathway[J].药物分析学报（英文）,2023,13(6):590-602,13.

基金项目

This work was supported by grants from the National Natural Science Foundation of China(Grant Nos.:82271158,82192865,and 82071045),and Wenzhou Municipal Science and Technology Research Program(Grant No.:2021Y0681). （Grant Nos.:82271158,82192865,and 82071045）

药物分析学报（英文）

OACSCD

2095-1779

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