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Construction and evaluation of the functional polygenic risk score for gastric cancer in a prospective cohort of the European population

Yuanliang Gu Caiwang Yan Tianpei Wang Beiping Hu Meng Zhu Guangfu Jin

中华医学杂志(英文版)2023,Vol.136Issue(14):1671-1679,9.
中华医学杂志(英文版)2023,Vol.136Issue(14):1671-1679,9.DOI:10.1097/CM9.0000000000002716

Construction and evaluation of the functional polygenic risk score for gastric cancer in a prospective cohort of the European population

Construction and evaluation of the functional polygenic risk score for gastric cancer in a prospective cohort of the European population

Yuanliang Gu 1Caiwang Yan 2Tianpei Wang 3Beiping Hu 3Meng Zhu 4Guangfu Jin5

作者信息

  • 1. Department of Epidemiology,School of Public Health,Southeast University,Nanjing,Jiangsu 210009,China||Department of Epidemiology,Center for Global Health,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China
  • 2. Department of Epidemiology,Center for Global Health,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China||Jiangsu Key Lab of Cancer Biomarkers,Prevention and Treatment,Collaborative Innovation Center for Cancer Personalized Medicine and China International Cooperation Center for Environment and Human Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China
  • 3. Department of Epidemiology,Center for Global Health,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China
  • 4. Department of Epidemiology,Center for Global Health,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China||Jiangsu Key Lab of Cancer Biomarkers,Prevention and Treatment,Collaborative Innovation Center for Cancer Personalized Medicine and China International Cooperation Center for Environment and Human Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China||Jiangsu Key Laboratory of Molecular and Translational Cancer Research,Jiangsu Cancer Hospital,Jiangsu Institute of Cancer Research,The Affiliated Cancer Hospital of Nanjing Medical University,Nanjing,Jiangsu 210009,China
  • 5. Department of Epidemiology,School of Public Health,Southeast University,Nanjing,Jiangsu 210009,China||Department of Epidemiology,Center for Global Health,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China||Jiangsu Key Lab of Cancer Biomarkers,Prevention and Treatment,Collaborative Innovation Center for Cancer Personalized Medicine and China International Cooperation Center for Environment and Human Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China||Jiangsu Key Laboratory of Molecular and Translational Cancer Research,Jiangsu Cancer Hospital,Jiangsu Institute of Cancer Research,The Affiliated Cancer Hospital of Nanjing Medical University,Nanjing,Jiangsu 210009,China
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摘要

关键词

Polygenic risk score/Gastric cancer/Polymorphism,single nucleotide/Cross ancestry

Key words

Polygenic risk score/Gastric cancer/Polymorphism,single nucleotide/Cross ancestry

引用本文复制引用

Yuanliang Gu,Caiwang Yan,Tianpei Wang,Beiping Hu,Meng Zhu,Guangfu Jin..Construction and evaluation of the functional polygenic risk score for gastric cancer in a prospective cohort of the European population[J].中华医学杂志(英文版),2023,136(14):1671-1679,9.

基金项目

This study was partly supported by grants from the National Natural Science Foundation of China(Nos.82125033,82230110,81872702,82003534,and 82273714),the Natural Science Foundation of Jiangsu Province(No.BK20200674),and CAMS Innovation Fund for Medical Sciences(No.2019RU038). (Nos.82125033,82230110,81872702,82003534,and 82273714)

中华医学杂志(英文版)

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