数字中医药（英文）2023，Vol.6Issue(2)：112-120,9.DOI:10.1016/j.dcmed.2023.07.002
黑孜然的肝脏保护和心血管保护作用:一项荟萃分析
Liver-protectant and cardiovascular-protectant effects of Nigella sativa:a meta-analysis
Fathiyah Safithri 1Diah Hermayanti 2Isbandiyah 3Probo Yudha Pratama Putra 4Faiq Shabri Maulana 4Aji Muthi'ah Nur Azizah4
作者信息
- 1. Department of Pharmacology,Medical Faculty University of Muhammadiyah Malang,Malang,East Java 65145,Indonesia
- 2. Department of Clinical Pathology,Medical Faculty University of Muhammadiyah Malang,Malang,East Java 65145,Indonesia
- 3. Department of Internal Medicine,Medical Faculty University of Muhammadiyah Malang,Malang,East Java 65145,Indonesia
- 4. Department of Medicine,Medical Faculty University of Muhammadiyah Malang,Malang,East Java 65145,Indonesia
- 折叠
摘要
Abstract
Objective A significant amount of evidence has lately revealed that individuals with non-alcoholic fatty liver diseases(NAFLD)are at high risk of cardiovascular diseases,which is the primary cause of death in patients.This study is to evaluate liver-and cardiovascular-protect-ant effects of Nigella sativa(N.sativa).Methods The meta-analysis was performed using Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)guidelines.The literature review was conducted in June 2022 with papers retrieved from the PubMed,ScienceDirect,and Cochrane Library web-sites from January 2010 to December 2021.The Review Manager version 5.3 was applied for the statistical analysis of parameters like aspartate transaminase(AST)and alanine transam-inase(ALT)levels,lipid profil,blood glucose level,weight,and body mass index(BMI).Results The results showed that N.sativacould significantly decrease the AST(P =0.009)and ALT(P<0.05)levels in research subjects.Subjects in the N.sativa group had a significant higher cure rate of fatty liver than those in the placebo group(P =0.000 1).In addition,lipid profile,blood pressure,and fasting blood glucose of subjects all significantly reduced in the N.sativa group(P<0.05).However,the comparison of body weight and BMI between the N.sativa group and placebo group did not show significant difference(P>0.05).Conclusion N.sativa did have certain liver-protectant and cardiovascular-protectant effects on patients with NAFLD or chronic liver diseases(CLD),despite the insignificant comparison of body weight and BMI between the N.sativa group and the placebo group.关键词
保肝药/保心药/黑孜然/血脂/肝酶/脂肪肝Key words
Hepatoprotectant/Cardioprotectant/Nigella sativa(N.sativa)/Lipid profile/Liver enzyme/Fatty liver引用本文复制引用
Fathiyah Safithri,Diah Hermayanti,Isbandiyah,Probo Yudha Pratama Putra,Faiq Shabri Maulana,Aji Muthi'ah Nur Azizah..黑孜然的肝脏保护和心血管保护作用:一项荟萃分析[J].数字中医药（英文）,2023,6(2):112-120,9.
