数字中医药（英文）2023，Vol.6Issue(2)：189-197,9.DOI:10.1016/j.dcmed.2023.07.008
大麻槿治疗尿石症和胆石症的临床前评价
Preclinical evaluation of Hibiscus cannabinus Linn.in the treatment of urolithiasis and cholelithiasis
Swathi Suresh 1Ankul Singh S 1Chitra Vellapandian1
作者信息
- 1. Department of Pharmacology,SRM College of Pharmacy,SRM Institute of Science and Technology,Kattankulathur,Tamil Nadu 603209,India
- 折叠
摘要
Abstract
Objective To investigate the therapeutic effect of Hibiscus cannabinus Linn.(H.cannabinus)leaves on cholelithiasis and urolithiasis.Methods The study evaluated the effect of aqueous leaf extract of H.cannabinus on thiouracil and cholesterol cholic acid diet induced cholelithiasis in BALB/c mice and ethylene glycol in-duced urolithiasis in Wistar rats.Three doses of aqueous extract(40,80,and 160 mg/kg)were selected to evaluate the effectiveness in cholelithiasis in mice;another three doses of aqueous extract(400,800,and 1 600 mg/kg)were administered for evaluating the effect on urolithiasis in rats.Biochemical parameters such as biliary cholesterol,biliary phospholipid,and bile acid were determined in cholelithiasis model.Similarly,24-hour urine output,urinary parameters such as creatinine,uric acid,protein,urea,presence of calcium oxalate crystals,red blood cells(RBCs),and pyuria were determined in urolithiasis model.Results Statistically significant differences were noted in the biliary and urinary parameters after administrating three test doses of H.cannabinus aqueous extract(P<0.05).Conclusion H.cannabinus was found to be effective against high fat lithogenic diet urolithi-asis and cholelithiasis.关键词
大麻槿/胆石症/尿石症/红麻/胆结石/肾结石Key words
Hibiscus cannabinus Linn.(H.can-nabinus)/Cholelithiasis/Urolithiasis/Kenaf/Gallstone/Kidney stone引用本文复制引用
Swathi Suresh,Ankul Singh S,Chitra Vellapandian..大麻槿治疗尿石症和胆石症的临床前评价[J].数字中医药（英文）,2023,6(2):189-197,9.
