日用化学工业（中英文）2023，Vol.53Issue(9)：999-1007,9.DOI:10.3969/j.issn.2097-2806.2023.09.002
基于脂质组学的敏感性皮肤表面脂质差异分析
Differential analysis of sensitive skin surface lipids based on lipidomics
摘要
Abstract
This paper established a method for collecting,detecting,and analyzing the human facial skin surface lipids based on lipidomics technology for the study of lipid metabolic disorders in sensitive skin.Firstly,the young female volunteers were divided into the sensitive skin group and non-sensitive skin group by lactic acid stinging test,then the physiological indices were detected and the facial skin surface lipids were analyzed by the ultra-high performance liquid chromatography-quadrupole-time of flight mass spectrometry(UPLC-Q-TOF-MS).Subsequently,the differential components were screened by orthogonal partial least-squares discrimination analysis(OPLS-DA)combined with t test and identified via high-resolution MS/MS,and totally 29 differential lipids of triglyceride(TG)were assigned.Compared with the non-sensitive skin group,the levels of these differential TGs are significantly reduced in the sensitive skin group,and the relevant biological significance is explained.This study provides theoretical guidance and technical support for the exploration of the pathogenesis of sensitive skin as well as the research and development of related skin care products.关键词
脂质组学/敏感性皮肤/差异性脂质/甘油三酯Key words
lipidomics/sensitive skin/differential lipids/triglyceride分类
化学化工引用本文复制引用
万宗元,佟薇,周淳,胡坪,欧阳胜,章弘扬..基于脂质组学的敏感性皮肤表面脂质差异分析[J].日用化学工业（中英文）,2023,53(9):999-1007,9.基金项目
国家自然科学基金资助项目(81973285) （81973285）
