人工晶体学报2023，Vol.52Issue(10)：1858-1866,9.
3-甲基吡啶悬臂Cu(Ⅱ)-Zn(Ⅱ)异双核配合物的合成、晶体结构及其与CT-DNA的结合活性
Synthesis,Crystal Structure,and CT-DNA Binding Activity of a 3-Methylpyridyl Pendant-Arms Cu(Ⅱ)-Zn(Ⅱ)Hetero-Binuclear Complex
摘要
Abstract
A new 3-methylpyridyl pendant-arms Cu(Ⅱ)-Zn(Ⅱ)hetero-binuclear complex was synthesized by condensation reaction of 3,3′-((ethane-1,2-diylbis((pyridin-2-ylmethyl)azanediyl))bis(methylene))bis(2-hydroxy-5-methylbenzaldehyde)(H2 L)and propane diamine in the presence of metal ions.The structure was characterized by IR spectroscopy,UV-Vis spectroscopy,ES-MS spectroscopy and X-ray single-crystal diffraction.The crystal structure reveals that the complex crystallizes in hexagonal,space group P63/m,with a = 1.98218(17)nm,b = 1.98218(17)nm and c = 1.8394(2)nm.The coordination environment of Zn(Ⅱ)and Cu(Ⅱ)in complex can be described as approximately square pyramid,where the apical positions are occupied by acetate radical.Two metal centers are equivalently bridged by the phenolic oxygens and an acetate radical with the intermetallic separation of 0.2897 nm.The interaction between the complex and calf thymus DNA(CT-DNA)was measured by cyclic voltammetry and viscosity studies,which shows a weak binding activity of 6.92×103mol/L.关键词
3-甲基吡啶悬臂/Cu(Ⅱ)-Zn(Ⅱ)异双核配合物/单晶衍射/配位环境/CT-DNA结合Key words
3-methylpyridyl pendant-arm/Cu(Ⅱ)-Zn(Ⅱ)hetero-binuclear complex/coordination environment/CT-DNA binding分类
化学化工引用本文复制引用
王洋,李铭,关金涛,张智勇,闫俊涛,熊兰,毛佳伟..3-甲基吡啶悬臂Cu(Ⅱ)-Zn(Ⅱ)异双核配合物的合成、晶体结构及其与CT-DNA的结合活性[J].人工晶体学报,2023,52(10):1858-1866,9.基金项目
Science and Technology of the State Administration of Market Regulation(2022MK111) （2022MK111）
Sichuan Natural Science Foundation(2023NSFSC1805) （2023NSFSC1805）
