首页|期刊导航|药物分析学报:英文版|Single-cell transcriptome analysis uncovers underlying mechanisms of acute liver injury induced by tripterygium glycosides tablet in mice

Single-cell transcriptome analysis uncovers underlying mechanisms of acute liver injury induced by tripterygium glycosides tablet in mice

Qiuyan Guo Jiangpeng Wu Qixin Wang Yuwen Huang Lin Chen Jie Gong Maobo Du Guangqing Cheng Tianming Lu Minghong Zhao Yuan Zhao Chong Qiu Fei Xia Junzhe Zhang Jiayun Chen Feng Qiu Jigang Wang

药物分析学报:英文版2023，Vol.13Issue(8)：P.908-925,18.

药物分析学报:英文版2023，Vol.13Issue(8)：P.908-925,18.DOI:10.1016/j.jpha.2023.03.004

Single-cell transcriptome analysis uncovers underlying mechanisms of acute liver injury induced by tripterygium glycosides tablet in mice

Qiuyan Guo ¹Jiangpeng Wu ²Qixin Wang ¹Yuwen Huang ³Lin Chen ¹Jie Gong ⁴Maobo Du ⁵Guangqing Cheng ¹Tianming Lu ¹Minghong Zhao ¹Yuan Zhao ⁶Chong Qiu ¹Fei Xia ¹Junzhe Zhang ¹Jiayun Chen ¹Feng Qiu ⁷Jigang Wang⁸

作者信息

1. State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs,Artemisinin Research Center,and Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing,100700,China
2. School of Chinese Materia Medica,and State Key Laboratory of Component-Based Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin,301617,China Department of Nephrology,Shenzhen Key Laboratory of Kidney Diseases,Shenzhen Clinical Research Centre for Geriatrics,Shenzhen People''s Hospital,The First Affiliated Hospital,Southern University of Science and Technology,Shenzhen,Guangdong,518020,China
3. College of Food Science and Engineering,Institute of Ocean,Bohai University,Jinzhou,Liaoning,121013,China
4. State Key Laboratory of Infectious Disease Prevention and Control,Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases,National Institute for Communicable Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing,102206,China
5. Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing,100700,China
6. The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine,Shenzhen,Guangdong,518033,China
7. School of Chinese Materia Medica,and State Key Laboratory of Component-Based Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin,301617,China
8. State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs,Artemisinin Research Center,and Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing,100700,China School of Chinese Materia Medica,and State Key Laboratory of Component-Based Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin,301617,China Department of Nephrology,Shenzhen Key Laboratory of Kidney Diseases,Shenzhen Clinical Research Centre for Geriatrics,Shenzhen People''s Hospital,The First Affiliated Hospital,Southern University of Science and Technology,Shenzhen,Guangdong,518020,China
折叠

摘要

关键词

Tripterygium glycosides tablet/Acute liver injury/scRNA-seq

分类

医药卫生

引用本文复制引用

Qiuyan Guo,Jiangpeng Wu,Qixin Wang,Yuwen Huang,Lin Chen,Jie Gong,Maobo Du,Guangqing Cheng,Tianming Lu,Minghong Zhao,Yuan Zhao,Chong Qiu,Fei Xia,Junzhe Zhang,Jiayun Chen,Feng Qiu,Jigang Wang..Single-cell transcriptome analysis uncovers underlying mechanisms of acute liver injury induced by tripterygium glycosides tablet in mice[J].药物分析学报:英文版,2023,13(8):P.908-925,18.

基金项目

supported by the National Key Research and Development Program of China(Grant Nos.:2020YFA0908000,2022YFC2303600) （Grant Nos.:2020YFA0908000,2022YFC2303600）

the Establishment of Sino-Austria“Belt and Road”Joint Laboratory on Traditional Chinese Medicine for Severe Infectious Diseases and Joint Research(Grant No.:2020YFE0205100) （Grant No.:2020YFE0205100）

the National Natural Science Foundation of China(Grant Nos.:82104480,82004248,82141001,82274182,82074098,82173914) （Grant Nos.:82104480,82004248,82141001,82274182,82074098,82173914）

the Fundamental Research Funds for the Central public welfare research institutes(Grant Nos.:ZZ14-YQ-055,ZZ14-YQ-059,ZZ14-YQ-060,ZXKT19018,ZXKT19021,ZXKT19022,ZZ14-YQ-050,ZZ14-YQ-051,ZZ14-YQ-052,ZZ14-FL-002,ZZ14-ND-010,ZZ15-ND-10,ZZ16-ND-10-19) （Grant Nos.:ZZ14-YQ-055,ZZ14-YQ-059,ZZ14-YQ-060,ZXKT19018,ZXKT19021,ZXKT19022,ZZ14-YQ-050,ZZ14-YQ-051,ZZ14-YQ-052,ZZ14-FL-002,ZZ14-ND-010,ZZ15-ND-10,ZZ16-ND-10-19）

the Beijing Municipal Natural Science Foundation(Grant No.:7214287) （Grant No.:7214287）

the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(Grant No.:ZYYCXTD-C-202002) （Grant No.:ZYYCXTD-C-202002）

the Young Elite Scientists Sponsorship Program by CACM(Grant No.:2021QNRC2B29) （Grant No.:2021QNRC2B29）

the CACMS Innovation Fund(Grant Nos.:CI2021A05101,CI2021A05104) （Grant Nos.:CI2021A05101,CI2021A05104）

the Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences(Grant No.:CI2021B014) （Grant No.:CI2021B014）

the Science and Technology Foundation of Shenzhen(Grant No.:JCYJ20210324115800001) （Grant No.:JCYJ20210324115800001）

the Science and Technology Foundation of Shenzhen(Shenzhen Clinical Medical Research Center for Geriatric Diseases) （Shenzhen Clinical Medical Research Center for Geriatric Diseases）

Shenzhen Governmental Sustainable Development Fund(Grant No.:KCXFZ20201221173612034) （Grant No.:KCXFZ20201221173612034）

Shenzhen key Laboratory of Kidney Diseases(Grant No.:ZDSYS201504301616234) （Grant No.:ZDSYS201504301616234）

Shenzhen Fund for Guangdong Provincial High-level Clinical Key Specialties(Grant No.:SZGSP001) （Grant No.:SZGSP001）

the Distinguished Expert Project of Sichuan Province Tianfu Scholar(Grant No.:CW202002) （Grant No.:CW202002）

the State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process Open Fund(Grant No.:SKL2020Z0302). （Grant No.:SKL2020Z0302）

药物分析学报:英文版

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ISSN：2095-1779

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