首页|期刊导航|药物分析学报:英文版|Single-cell analyses reveal cannabidiol rewires tumor microenvironment via inhibiting alternative activation of macrophage and synergizes with anti-PD-1 in colon cancer

Single-cell analyses reveal cannabidiol rewires tumor microenvironment via inhibiting alternative activation of macrophage and synergizes with anti-PD-1 in colon cancer

Xiaofan Sun Lisha Zhou Yi Wang Guoliang Deng Xinran Cao Bowen Ke Xiaoqi Wu Yanhong Gu Haibo Cheng Qiang Xu Qianming Du Hongqi Chen Yang Sun

药物分析学报:英文版2023，Vol.13Issue(7)：P.726-744,19.

药物分析学报:英文版2023，Vol.13Issue(7)：P.726-744,19.DOI:10.1016/j.jpha.2023.04.013

Single-cell analyses reveal cannabidiol rewires tumor microenvironment via inhibiting alternative activation of macrophage and synergizes with anti-PD-1 in colon cancer

Xiaofan Sun ¹Lisha Zhou ²Yi Wang ³Guoliang Deng ²Xinran Cao ²Bowen Ke ⁴Xiaoqi Wu ⁵Yanhong Gu ⁶Haibo Cheng ⁷Qiang Xu ²Qianming Du ⁸Hongqi Chen ⁹Yang Sun¹⁰

作者信息

1. Department of Rheumatology and Immunology,Nanjing Drum Tower Hospital,The Affiliated Hospital of Nanjing University Medical School,Nanjing University,Nanjing,210008,China State Key Laboratory of Pharmaceutical Biotechnology,School of Life Sciences,Nanjing University,Nanjing,210023,China
2. State Key Laboratory of Pharmaceutical Biotechnology,School of Life Sciences,Nanjing University,Nanjing,210023,China
3. Colon and Rectal Surgery,Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine,Nanjing,210001,China
4. Laboratory of Anesthesia and Critical Care Medicine,Department of Anesthesiology,Translational Neuroscience Center,West China Hospital and State Key Laboratory of Biotherapy,Sichuan University,Chengdu,610044,China
5. Genergy Bio-technology(Shanghai)Co.,Ltd,Shanghai,200241,China
6. The First Affiliated Hospital of Nanjing Medical University,Jiangsu Province Hospital,Nanjing,210029,China
7. Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine in Prevention and Treatment of Tumor,The First Clinical College of Nanjing University of Chinese Medicine,Nanjing,210023,China
8. General Clinical Research Center,Nanjing First Hospital,Nanjing Medical University,Nanjing,210006,China School of Basic Medicine&Clinical Pharmacy,China Pharmaceutical University,Nanjing,210009,China
9. Department of General Surgery,Shanghai Jiao Tong University Affiliated Sixth People''s Hospital,Shanghai,200030,China
10. Department of Rheumatology and Immunology,Nanjing Drum Tower Hospital,The Affiliated Hospital of Nanjing University Medical School,Nanjing University,Nanjing,210008,China State Key Laboratory of Pharmaceutical Biotechnology,School of Life Sciences,Nanjing University,Nanjing,210023,China Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy,Xuzhou Medical University,Xuzhou,Jiangsu,221004,China
折叠

摘要

关键词

scRNA-seq/scATAC-seq/Cannabidiol/Colorectal cancer/Tumor microenvironment/Macrophage

分类

医药卫生

引用本文复制引用

Xiaofan Sun,Lisha Zhou,Yi Wang,Guoliang Deng,Xinran Cao,Bowen Ke,Xiaoqi Wu,Yanhong Gu,Haibo Cheng,Qiang Xu,Qianming Du,Hongqi Chen,Yang Sun..Single-cell analyses reveal cannabidiol rewires tumor microenvironment via inhibiting alternative activation of macrophage and synergizes with anti-PD-1 in colon cancer[J].药物分析学报:英文版,2023,13(7):P.726-744,19.

基金项目

supported by the National Key Research and Development Plan,China(Grant No.:2022YFC3500202) （Grant No.:2022YFC3500202）

the Natural Science Foundation of China(Grant Nos.:82172558,and 82205024) （Grant Nos.:82172558,and 82205024）

the Scientific and Technological Innovation Action Plan of Natural Science Foundation Project of Shanghai,China(Grant No.:22ZR1447400) （Grant No.:22ZR1447400）

the Scientific and Technological Innovation Action Plan,China(Grant No.:22ZR1447400) （Grant No.:22ZR1447400）

the Fundamental Research Funds for the Central Universities,China(Grant Nos.:020814380179,020814380174) （Grant Nos.:020814380179,020814380174）

the Distinguished Young Scholars of Nanjing,China(Grant No.:JQX20008) （Grant No.:JQX20008）

the School of Life Science(NJU)-Sipimo Joint Funds and Mountain Climbing Talents Project of Nanjing University,China(Grant No.:2015018). （NJU）

药物分析学报:英文版

OACSCD

ISSN：2095-1779

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