首页|期刊导航|药物分析学报:英文版|Discovering metabolic vulnerability using spatially resolved metabolomics for antitumor small molecule-drug conjugates development as a precise cancer therapy strategy

Discovering metabolic vulnerability using spatially resolved metabolomics for antitumor small molecule-drug conjugates development as a precise cancer therapy strategy

Xiangyi Wang Jin Zhang Kailu Zheng Qianqian Du Guocai Wang Jianpeng Huang Yanhe Zhou Yan Li Hongtao Jin Jiuming He

药物分析学报:英文版2023，Vol.13Issue(7)：P.776-787,12.

药物分析学报:英文版2023，Vol.13Issue(7)：P.776-787,12.DOI:10.1016/j.jpha.2023.02.010

Discovering metabolic vulnerability using spatially resolved metabolomics for antitumor small molecule-drug conjugates development as a precise cancer therapy strategy

Xiangyi Wang ¹Jin Zhang ¹Kailu Zheng ²Qianqian Du ²Guocai Wang ¹Jianpeng Huang ¹Yanhe Zhou ¹Yan Li ²Hongtao Jin ³Jiuming He¹

作者信息

1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,100050,China NMPA Key Laboratory of Safety Research and Evaluation of Innovative Drug,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,100050,China
2. Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,100050,China
3. NMPA Key Laboratory of Safety Research and Evaluation of Innovative Drug,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,100050,China New Drug Safety Evaluation Center,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,100050,China
折叠

摘要

关键词

Mass spectrometry imaging/Spatially resolved metabolomics/Small molecule-drug conjugate/Tumor metabolism/Targeted tumor therapy

分类

资源环境

引用本文复制引用

Xiangyi Wang,Jin Zhang,Kailu Zheng,Qianqian Du,Guocai Wang,Jianpeng Huang,Yanhe Zhou,Yan Li,Hongtao Jin,Jiuming He..Discovering metabolic vulnerability using spatially resolved metabolomics for antitumor small molecule-drug conjugates development as a precise cancer therapy strategy[J].药物分析学报:英文版,2023,13(7):P.776-787,12.

基金项目

supported by the National Natural Science Foundation of China(Grant Nos.:81974500,81773678) （Grant Nos.:81974500,81773678）

the CAMS Innovation Fund for Medical Sciences(Grant No.:2022-I2M-2-001). （Grant No.:2022-I2M-2-001）

药物分析学报:英文版

OACSCD

ISSN：2095-1779

访问量0

下载量0

段落导航