摘要
Abstract
Objective To re-evaluate systematic reviews/meta analyses(SRs/MAs)of docetaxel-cisplatin-fluorouracil(TPF)combined induction chemotherapy for head and neck cancer(HNC).Methods The SRs/MAs of TPF induction chemotherapy compared with cisplatin-fluorouracil(PF)induction chemotherapy for HNC were collected from the PubMed,Web of science,Embase,CNKI,VIP database,Wanfang and CBM databases.The quality evaluation of the included SRs/MAs was performed using the AMSTAR 2 tool,and the quality of evidence was graded using the GRADE grading system.Results A total of 8 SRs/MAs were included.The results showed that the TPF induction chemotherapy has some advantages over the traditional PF induction chemotherapy in improving the overall response rate,complete response rate,survival rate,and progression-free survival rate.In terms of toxic reactions,the incidence of leukopenia,neutropenic fever,diarrhea,and alopecia was relatively high in the TPF induction chemotherapy regimen.The incidence of thrombocytopenia and stomatitis was relatively high in the PF chemotherapy regimen.The methodological quality and level of evidence of included SRs/MAs were generally low.Conclusion The current evidence shows that TPF induction chemotherapy is more effective than PF induction chemotherapy in the treatment of HNC.However,the quality evaluation results of the included studies were too low.Therefore,more high-quality studies should be conducted in the future,and rigorous design schemes should be developed to improve the quality of the SRs/MAs.关键词
紫杉类/顺铂/氟尿嘧啶/头颈部肿瘤/系统评价再评价Key words
Docetaxel/Cisplatin/Fluorouracil/Head and neck cancer/Overview of systematic reviews分类
医药卫生
