南方医科大学学报2023，Vol.43Issue(11)：1833-1838,6.DOI:10.12122/j.issn.1673-4254.2023.11.01
药物过度使用性头痛患者脑内铁沉积分布的定量磁敏感成像研究
Brain iron deposition increases in the bilateral substantia nigra of patients with medication-overuse headache:a quantitative susceptibility mapping analysis
李鑫 1赵赫 2刘梦琦 3陈志晔1
作者信息
- 1. 解放军总医院海南医院放射科,海南 三亚 572013||南方医科大学第二临床医学院,广东 广州 510515
- 2. 解放军总医院第一医学中心神经内科医学部,北京 100853
- 3. 解放军总医院海南医院放射科,海南三亚572013||解放军总医院第一医学中心放射科,北京 100853
- 折叠
摘要
Abstract
Objective To investigate iron accumulation level over the whole brain and explore the possible neuromechanism of medication-overuse headache(MOH)using quantitative susceptibility mapping(QSM).Methods Thirty-seven MOH patients and 27 normal control subjects were enrolled in the study for examinations with both a multi-echo gradient echo magnetic resonance(MR)sequence and brain high resolution structural imaging.A voxel-based analysis was performed to detect the brain regions with altered iron deposition,and the quantitative susceptibility mapping values of the positive brain regions were extracted.Correlation analysis was performed between the susceptibility values and the clinical variables of the patients.Results In patients with MOH,increased susceptibility values were found mainly in the bilateral substantia nigra(SN)(MNI coordinate:8,-18,-14;-6,-16,-14)as compared with the normal control subjects(P<0.001),but these alterations in iron deposition were not significantly correlated with the clinical variables of the patients(P>0.05).The susceptibility value in the left SN had an area under curve(AUC)of 0.734,and at the cut-off value of 0.077,its diagnostic sensitivity was 72.97%and its specificity was 70.37%for distinguishing MOH from normal controls;The susceptibility value in the right SN had an AUC of 0.699 with a diagnostic sensitivity of 72.97%and a specificity of 62.96%at the cut-off value of 0.084.Conclusion Increased iron deposition occurs in the bilateral SN of MOH patients,which provides a new insight into the mechanism of mesocorticolimbic dopamine system dysfunction in MOH.QSM technique can be used as a non-invasive means for quantitative analysis of brain iron deposition in migraine neuroimaging.关键词
药物过度使用性头痛/定量磁敏感成像/脑/基于体素的分析/铁沉积Key words
medication-overuse headache/quantitative susceptibility mapping/brain/voxel-based analysis/iron deposition引用本文复制引用
李鑫,赵赫,刘梦琦,陈志晔..药物过度使用性头痛患者脑内铁沉积分布的定量磁敏感成像研究[J].南方医科大学学报,2023,43(11):1833-1838,6.
