临床与病理杂志2023，Vol.43Issue(9)：1642-1648,7.DOI:10.11817/j.issn.2095-6959.2023.230247
甘油三酯-葡萄糖指数与急性卒中后认知障碍相关性分析
Correlation between triglyceride-glucose index and post-stroke cognitive impairment
摘要
Abstract
Objective:Acute ischemic stroke(AIS)is characterized by a high incidence,disability,mortality,and recurrence rate.Post-stroke cognitive impairment(PSCI)has a high occurrence rate.Recent studies have found a correlation between the triglyceride-glucose(TyG)index and dementia.This study explores the relationship between the TyG index and the occurrence of PSCI in patients with AIS. Methods:Clinical data from AIS patients with confirmed diagnoses who were admitted to the Department of Neurology of the Hospital from January to June 2021 were retrospectively analyzed.The Montreal Cognitive Assessment(MoCA)assessed cognitive function,and the enrolled patients were divided into the PSCI group(n=92)and the non-PSCI group(n=31).The receiver operator characteristic(ROC)curve was used to evaluate the predictive value of the TyG index for PSCI.Patients were divided into low and high TyG index groups according to the optimal truncation value of the TyG index.Binary Logistic regression was used to analyze the correlation between the TyG index and PSCI. Results:The TyG index level in the PSCI group was significantly higher than that in the non-PSCI group(9.22±0.53 vs 8.80±0.65,P<0.05).The area under the ROC curve was 0.71(95%CI 0.59 to 0.85,P<0.05),and the optimal truncation value of the TyG index for predicting PSCI was 8.72,with a sensitivity of 53.30%,and specificity of 87.10%.Logistic regression showed a positive correlation between the TyG index and the risk of PSCI. Conclusion:The TyG index is associated with cognitive impairment caused by AIS and is an independent factor for the occurrence of PSCI.关键词
甘油三酯-葡萄糖指数/急性缺血性卒中/卒中后认知障碍Key words
triglyceride-glucose index/acute ischemic stroke/post-stroke cognitive impairment引用本文复制引用
黄妍,王羲淳,邹良玉..甘油三酯-葡萄糖指数与急性卒中后认知障碍相关性分析[J].临床与病理杂志,2023,43(9):1642-1648,7.基金项目
深圳市基础研究专项重点项目(JCYJ20200109144418639).This work was supported by the Shenzhen Basic Research Project,China(JCYJ20200109144418639). （JCYJ20200109144418639）
