临床与病理杂志2023，Vol.43Issue(9)：1664-1669,6.DOI:10.11817/j.issn.2095-6959.2023.230156
重症急性胰腺炎患者再喂养综合征的危险因素及预后
Risk factors and prognosis of refeeding syndrome in patients with severe acute pancreatitis
张婧 1何芸 1朱梦莉 1童丽2
作者信息
- 1. 武汉市第一医院急诊科,武汉 430030
- 2. 华中科技大学同济医学院附属协和医院神经外科,武汉 430022
- 折叠
摘要
Abstract
Objective:To investigate the risk factors of refeeding syndrome(RFS)in patients with severe acute pancreatitis(SAP)and analyze the relationship between RFS and prognosis.
Methods:Clinical data of 102 SAP patients admitted to the Wuhan First Hospital from January 2020 to October 2022 were retrospectively selected to analyze the incidence of RFS.The occurrence of RFS was recorded,and the patients were divided into a RFS group(n=52)and a non-RFS group(n=50).Multiple logistic regression was used to analyze factors affecting the occurrence of RFS in SAP patients.The Kaplan-Meier and Log-Rank were used to compare the in in-hospital survival rates between the RFS and non-RFS groups.
Results:There were 52 cases of RFS.The RFS group had a higher average age than the non-RFS group(P<0.05).The body mass index and serum PO3-4 level at admission were lower in the RFS group than those in the non-RFS group(both P<0.05).The RFS group had a higher proportion of chronic alcoholism history,fasting time≥5 days,higher Nutritional Risk Screening 2002(NRS 2002)score,higher Acute Physiological Assessment and Chronic Health Evaluation II(APACHEII)score,and higher Sequential Organ Failure Assessment(SOFA)score compared to the non-RFS group(all P<0.05).The daily caloric intake was higher in the RFS group compared to the non-RFS group(P<0.05).Multivariate logistic regression analysis showed that the chronic alcoholism history and fasting time≥5 days were risk factors for RFS in the SAP patients(both P<0.05),while higher body mass index and serum PO3-4 level at admission were protective factors(both P<0.05).The in-hospital mortality rate was higher in the RFS group than that in the non-RFS group(χ2= 5.220,P<0.05).
Conclusion:Chronic alcoholism history,fasting time,low body mass index and serum PO3-4 level at admission are the related factors for the occurrence of RFS in SAP patients,and the RFS increases the risk of in-hospital mortality in SAP patients.关键词
重症急性胰腺炎/再喂养综合征/酗酒/磷酸盐水平/危险因素/预后Key words
severe acute pancreatitis/refeeding syndrome/alcoholism/phosphate/risk factors/prognosis引用本文复制引用
张婧,何芸,朱梦莉,童丽..重症急性胰腺炎患者再喂养综合征的危险因素及预后[J].临床与病理杂志,2023,43(9):1664-1669,6.
