临床与病理杂志2023，Vol.43Issue(9)：1677-1682,6.DOI:10.11817/j.issn.2095-6959.2023.230137
BTN3A2在肿瘤中作用的研究进展
Research progress in the role of BTN3A2 in cancer
摘要
Abstract
Lactophilin subfamily 3 member A2(BTN3A2)is an immunologically relevant transmembrane protein and expressed in immune cells such as B cells,monocytes,and dendritic cells.In recent years,the studies of BTN3A2 in cancer primarily focus on triple-negative breast cancer,pancreatic ductal adenocarcinoma,ovarian epithelial carcinoma,lung adenocarcinoma,and gastric adenocarcinoma,where it exhibits differential expression in various tumor tissues.Its expression can be upregulated by pro-inflammatory cytokines like interferon-γ(IFN-γ)and tumor necrosis factor-α(TNF-α).BTN3A2 enhances CD8+ and CD4+ T cells and dendritic cells in tumor microenvironment by regulating T cell mediated transcription regulator factor T-bet,signal transducer and activator of transcription(STAT)1,IFN-γ;activation/inhibition of NF-κB signaling pathway,IL-2(interleukin-2)/STAT3 signaling pathway.By inducing γδ T cells to activate into Vγ9Vδ2 T cells,anti-tumor effect can be achieved.Further analysis shows that hsa-miR-17-5p may be a miRNA target of BTN3A2,which may be provide new insights into cancer immunotherapy.关键词
嗜乳脂蛋白亚家族3成员A2/肿瘤/免疫应答Key words
lactophilin subfamily 3 member A2/cancer/immune response引用本文复制引用
王静静,李东坤,谭玲,雷丰丰..BTN3A2在肿瘤中作用的研究进展[J].临床与病理杂志,2023,43(9):1677-1682,6.基金项目
国家自然科学基金(41961016).This work was supported by the National Natural Science Foundation of China(41961016). （41961016）
