摘要
Abstract
Gastric cancer(GC)is the most common malignant tumor in the digestive system,characterized by high incidence and poor prognosis.The chemokine ligand 12(CXCL12)-chemokine receptor(CXCR)4/CXCR7 axis and its downstream signaling pathways are involved in the initiation and progression of gastric cancer.When CXCL12 binds to CXCR4,it regulates the expression of vascular endothelial growth factor(VEGF)by inducing epithelial-mesenchymal transition(EMT),activates various signaling pathways,such as phosphatidylinositol 3-kinase/protein kinase B(PI3K/Akt),Wnt signaling pathway,and nuclear factor-kappa B(NF-κB)and other mechanisms,and enhances proliferation,invasion,and metastasis in GC.Coversely,CXCL12 binding to CXCR7 increases the expression of matrix metalloproteinases(MMP)-2 and MMP-9 in GC cells,thus promoting their migration and invasion capabilities.Furthermore,the CXCL12-CXCR4/CXCR7 axis accelerates GC progression by regulating protein kinase B(Akt),signal transducer and activator of transcription 3/myelocytomatosis viral oncogene homolog(STAT3/c-Myc)signaling pathways.Additionally,this axis is closely related to tumor immune response in GC and mediates the development of immune cells,such as T cells,B cells,NK cells,macrophages,and neutrophils,suggesting new prospects for GC immunotherapy.关键词
胃癌/趋化因子配体12/趋化因子受体4/趋化因子受体7Key words
gastric cancer/chemokine ligand 12/chemokine receptor 4/chemokine receptor 7
