临床与病理杂志2023，Vol.43Issue(9)：1690-1697,8.DOI:10.11817/j.issn.2095-6959.2023.220079
细胞焦亡的分子机制及其在肿瘤治疗中的应用
Molecular mechanism of pyroptosis and its application in the treatment of tumor
摘要
Abstract
Pyroptosis,a lytic pro-inflammatory type of programmed cell death,has been widely studied in diverse models of inflammatory diseases.Membrane perforation and cell swelling induced by cleaved Gasdermin family members is the main characteristic of pyroptosis.There are 2 main molecular mechanisms of pyroptosis:the classical caspase-1-dependent pathway and the non-caspase-1-dependent pathway.Both pathways lead to cell swelling and the release of pro-inflammatory cytokines interleukin(IL)-1β and IL-18,and expand local or systemic inflammation.The relationship between pyroptosis and tumors is complex.On one hand,pyroptosis can build a microenvironment conducive to tumor cell proliferation and accelerate tumor progression.On the other hand,overactivation of pyroptosis can inhibit the progression of tumor cells.Inducing target cells to undergo pyroptosis by regulating the expression of Gasdermin family member,inflammasomes,and other pyroptosis-related factors can be a therapeutic method for various cancers,such as non-small cell lung cancer,gastric cancer,colorectal cancer,hepatocellular carcinoma,leukemia,and cervical cancer.Exploring the role of pyroptosis in tumor therapy is of great significance for the development of novel strategies in tumor treatment.关键词
细胞焦亡/肿瘤/caspase家族/Gasdermin家族Key words
pyroptosis/tumor/caspase family/Gasdermin family引用本文复制引用
龚晓文,梁超杰..细胞焦亡的分子机制及其在肿瘤治疗中的应用[J].临床与病理杂志,2023,43(9):1690-1697,8.基金项目
山西省应用基础研究计划项目(201901D211480).This work was supported by the Applied Basic Research Program of Shanxi Province,China(201901D211480). （201901D211480）
