中国实用神经疾病杂志2023，Vol.26Issue(12)：1573-1577,5.DOI:10.12083/SYSJ.230885
二代测序技术在颅内感染中的应用
Application of second-generation sequencing technology in intracranial infection
摘要
Abstract
Intracranial infection is one of the most common neurosurgical diseases and one of the most serious postoperative complications of neurosurgery.They progress as a result of the interaction of the infected microorganisms with the host.The key issues in curing intracranial infections are early and accurate identification of the infecting pathogen and precise use of pathogenically effective antibiotics.Identifying the pathogens responsible for intracranial infections is not an easy task when relying only on traditional testing methods.In recent years,the rapid development of second-generation sequencing technology(NGS)has made it possible to identify infectious pathogens at an early stage,and this technology can detect pathogens in a high-throughput,rapid,and efficient manner with high precision while also providing guidance for clinical drug use.NGS,as a new mean of detecting pathogens,has attracted a great deal of attention since its inception,and this article provides an overview of its application to intracranial infections caused by different pathogens,in order to let clinicians fully understand its advantages and disadvantages,so that NGS technology can play a greater role in the diagnosis of intracranial infections,thus alleviating the pain of patients.关键词
颅内感染/二代测序技术/神经外科/脑脊液/病原微生物Key words
Intracranial infections/Second-generation sequencing technology/Neurosurgery/Cerebrospi-nal fluid/Pathogenic microorganisms分类
医药卫生引用本文复制引用
吴佳诺,苏高健,邓宇航,李欣梦,刘紫薇,黄贤键..二代测序技术在颅内感染中的应用[J].中国实用神经疾病杂志,2023,26(12):1573-1577,5.基金项目
广东省自然科学基金面上项目(编号:2023A1515010320) （编号:2023A1515010320）
