中国实用神经疾病杂志2023，Vol.26Issue(12)：1578-1584,7.DOI:10.12083/SYSJ.230870
GM-CSF在神经退行性疾病炎性反应过程中的作用
Role of GM-CSF in inflammatory response during neurodegenerative diseases
摘要
Abstract
Neurodegenerative diseases are chronic progressive disorders that primarily affect the central nervous system(CNS).These diseases are characterized by the gradual loss of neuronal structure and function,closely associated with inflammatory processes.Inflammation within the central nervous system,referred to as neuroinflammation,is implicated in various neurodegenerative diseases such as Alzheimer's disease(AD),Parkinson's disease(PD),and multiple sclerosis(MS).GM-CSF,as a pro-inflammatory cytokine,plays a crucial role in the development of chronic inflammation and is believed to have wide-ranging effects on the occurrence and progression of central nervous system neurodegenerative diseases.This review summarizes the inflammatory response processes of GM-CSF in neurodegenerative diseases,providing clinical evidence for further exploration of its potential role in relevant therapies.Elucidating the molecular mechanisms of neurodegenerative diseases will offer effective targets for combating inflammatory responses associated with neurodegenerative diseases.关键词
粒细胞巨噬细胞集落刺激因子/神经退行性疾病/神经炎症/阿尔茨海默病/帕金森病/多发性硬化症Key words
Granulocyte-macrophage colony-stimulating factor/Neurodegenerative diseases/Inflammation/Alzheimer's Disease/Parkinson's disease/Multiple sclerosis分类
医药卫生引用本文复制引用
李嫚芹,张如意..GM-CSF在神经退行性疾病炎性反应过程中的作用[J].中国实用神经疾病杂志,2023,26(12):1578-1584,7.基金项目
湖北省教育厅科学技术研究项目(编号:B2022190) （编号:B2022190）
