摘要
Abstract
Objective We conducted a meta-analysis to clarify the association between STK39 and hypertension.Meth-ods Published literatures from PubMed,EMBASE,Web of science,and the Cochrane Library were retrieved,and combined odds ratios(OR)of 95％confidence intervals(CI)were calculated using fixed or random effects models.Results Using appropriate inclusion/exclusion criteria,we identified twelve studies that included 24,267 patients with hypertension and 15,935 controls from various ethnic groups.Meta-analysis showed no correlation between STK39 rs3754777 rs35929607 rs6749447 and hyper-tension.The corresponding OR values,95％CI and p values were:[1.15,(0.91,1.46),0.23],[0.95,(0.85,1.06),0.37],[1.18,(0.87,1.61),0.30].In subgroup analysis of populations by race,experimental design,sample size,and year of publication,we showed that studies involving white populations(OR=1.37,95％CI=1.16,1.62,P＜0.05)and prospective design stud-ies(OR=1.36,95％CI=1.01,1.83,P＜0.05),sample size ≥1500(OR=1.44,95％CI=1.01,2.06,P＜0.05),and publica-tion year prior to 2014(excluding 2014)(OR=1.1 1,95％CI=1.02,1.22,P＜0.05)were statistically significant.These studies indicate that site rs3754777 is associated with hypertension.We further confirmed the results through sensitivi-ty analysis.No publication bias was detected.Conclusions The present meta-analysis confirmed no significant associ-ation between STK39 and hypertension,and it is not recommended to study the pathogenesis of SPAK kinase as a pre-ventive measure for hypertension.关键词
STK39/基因多态性/原发性高血压/荟萃分析Key words
STK39/Polymorphism/Essential hypertension/Meta-analysis分类
医药卫生
