疾病监测与控制2023，Vol.17Issue(4)：253-257,262,6.DOI:10.19891/j.issn1673-9388.(2023)04-0253-06
直肠癌放化疗后未行手术的回顾性研究
A RETROSPECTIVE STUDY OF RECTAL CANCER WITHOUT SURGERY AFTER RADIOCHEMOTHERAPY IN THE REAL WORLD
摘要
Abstract
Objective To summarize and analyze the efficacy and prognosis of rectal cancer patients who did not undergo surgery after chemoradiotherapy for various reasons.Methods A retrospective analysis of 52 patients with rectal cancer who did not undergo surgery after chemoradiotherapy in our department from February 2012 to October 2021.Clinical remission and inci-dence of adverse reactions were analyzed.Kaplan-Meier method was used to calculate the overall survival(OS),and univariate analysis was used to analyze the risk factors for survival.Results After treatment,the local remission rate was 82.6％,CR rate was 5.7％,PR rate 76.9％,SD rate 13.5％and PD rate 3.8％;The 1-yearOSwas59.3％.The 1-year OS of 11 metastatic rec-tal cancer patients was 36.4％.The 1-year OS of 41 locally advanced rectal cancer patients was 65.5％.Most of the ad-verse reactions during treatment are grade 1 or 2,which could be alleviated after symptomatic and supportive treatment.Univariate analysis showed that M stage was significantly associated with 1-year OS.Conclusions For rectal cancer patients without surgery after chemoradiotherapy,the local remission rate of patients after chemoradiotherapy is high,and the adverse reactions are tolerable.Patients with cCR may benefit from watch and wait Strategy.M1 stage at initial diagnosis is significantly associated with poor survival outcomes.关键词
直肠癌/放化疗/疗效/不良反应/观察等待策略Key words
Rectal cancer/Chemoradiotherapy/Curative effect/Adverse reaction/Watch and wait strategy分类
医药卫生引用本文复制引用
陈虹,宝莹娜,乌新林,林宇,安志玲,梁骁,赵建国..直肠癌放化疗后未行手术的回顾性研究[J].疾病监测与控制,2023,17(4):253-257,262,6.基金项目
内蒙古科技计划项目(2019GG150) （2019GG150）
