基础医学与临床2023，Vol.43Issue(12)：1796-1800,5.DOI:10.16352/j.issn.1001-6325.2023.12.1796
南宁地区健康人群血清鳞状上皮细胞癌抗原参考区间的建立
Establishment of reference intervals of squamous cell carcinoma antigen for healthy population in Nanning region
摘要
Abstract
Objective To establish a reference intervals(RIs)of serum squamous cell carcinoma antigen(SCC-Ag)in healthy population in Nanning region and provide clinical evidence to support diagnosis and prognosis of squamous cell carcinoma.Methods A total of 10 197 reference individuals who joined a routine physical examina-tion in the Health Management Center of Guangxi International Zhuang Medical Hospital from March 2019 to De-cember 2021 were collected.The level of serum SCC-Ag was detected by chemiluminescence microparticle immuno-assay.The Mann-Whitney U test was applied to compare the differences in serum SCC level between genders or ad-jacent age groups.The unilateral 95th percentile determined the upper limit of the RIs by the nonparametric method.Another 1 035 healthy subjects with the same conditions as the reference population were selected for refer-ence validation.Results The serum SCC-Ag level showed a skewed distribution(Z＝0.08,P＜0.05).The ser-um SCC-Ag level of males was considerably higher than that of females.There was significant difference in serum SCC-Ag level between males aged 18－30 and 31－40,51－60 and 61－90(P＜0.05).There was significant difference in serum SCC-Ag level between females aged 18－30 and 31－40,31－40 and 41－50,51－60 and 61－ 90(P＜0.05).The reference intervals of serum SCC-Ag was as follows:0－1.64 ng/mL for males and females aged 18－30 years;0－1.57 ng/mL and 0－1.70 ng/mL for males aged 31－60 years and 61－90 years,respec-tively;0－1.50 ng/mL,0－1.52 ng/mL and 0－1.42 ng/mL for females aged 31－40 years,41－60 years and 61－90 years,respectively.Conclusions The RIs of serum SCC-Ag in healthy population in the Nanning region are successfully established according to different genders and ages.关键词
鳞状上皮细胞癌抗原/参考区间/鳞状上皮细胞癌Key words
squamous cell carcinoma antigen/reference interval/squamous cell carcinoma分类
医药卫生引用本文复制引用
周冬谊,韦玉红,易莉玲,韦尚谋,朱春玲,杨素芳,彭契六..南宁地区健康人群血清鳞状上皮细胞癌抗原参考区间的建立[J].基础医学与临床,2023,43(12):1796-1800,5.基金项目
广西中医药大学引进博士科研启动基金(2019BS042) （2019BS042）
广西国际壮医医院优势学科项目(院字[2021]33 号) （院字[2021]33 号）
