解放军医学杂志2023，Vol.48Issue(11)：1267-1275,9.DOI:10.11855/j.issn.0577-7402.2532.2023.0530
右美托咪定的器官保护作用及其机制概述
Research progress on organ protective effects and mechanisms of dexmedetomidine
摘要
Abstract
Dexmedetomidine is a highly selective α2 adrenergic receptor agonist,exerting anti-sympathetic,sedative,analgesic and anti-anxiety effects,with minimal impact on respiration.In recent years,dexmedetomidine has been widely used in clinical anesthesia,perioperative treatment,and intensive care.Organ-protection is an important focus of anesthesia and perioperative medicine,with clinical significance in reducing complications and improving short-and long-term outcomes.Increasing clinical evidence and basic research have shown that the application of dexmedetomidine could protect the heart,brain,lung,kidney,liver,gastrointestinal tract and other important organs.The mechanism may be related to dexmedetomidine's effects of anti-inflammation,anti-oxidation,anti-apoptosis,and autophagy regulation.From our perspectives,clinical use should follow the principle of individualization,and the dose should be adjusted in time according to patients'responses,so as to avoid adverse reactions such as hypotension and bradycardia while protecting the organs.Moreover,more strictly designed clinical studies and in-depth mechanistic investigations are needed for the optimal dexmedetomidine therapy and better organ protection during the perioperative course.In order to facilitate better understanding of clinicians,this paper reviews the organ-protective effects and underlying mechanisms of dexmedetomidine.关键词
右美托咪定/器官保护/麻醉/围手术期Key words
dexmedetomidine/organ protection/anesthesia/perioperative period分类
医药卫生引用本文复制引用
丁允莹,嵇富海,彭科..右美托咪定的器官保护作用及其机制概述[J].解放军医学杂志,2023,48(11):1267-1275,9.基金项目
This work was supported by the National Natural Science Foundation of China(82072130,81873925),and the Jiangsu Provincial Medical Youth Talents Program(QNRC2016741) 国家自然科学基金项目(82072130,81873925) （82072130,81873925）
江苏省青年重点医学人才项目(QNRC2016741) （QNRC2016741）
