山东医药2023，Vol.63Issue(34)：6-10,5.DOI:10.3969/j.issn.1002-266X.2023.34.002
血清Beclin1、SIRT6水平与ST段抬高型心肌梗死患者PCI术后缺血再灌注损伤的关系
Relationships between serum Beclin1 and SIRT6 levels and postoperative ischemia-reperfusion injury in STEMI patients
摘要
Abstract
Objective To investigate the relationships between serum Beclin1(BECN1)and silent information regu-lator transcript 6(SIRT6)levels and postoperative ischemia-reperfusion injury(IRI)in patients with ST-segment elevation myocardial infarction(STEMI).Methods Totally 150 STEMI patients were selected as the STEMI group,and then were divided into the IRI and non-IRI groups according to whether IRI occurred after percutaneous coronary intervention(PCI),and meanwhile,68 healthy volunteers with physical examination were selected as the control group during the same period.Serum BECN1 and SIRT6 levels were measured by enzyme-linked immunosorbent assay.We analyzed the factors influencing postoperative IRI in STEMI patients,and receiver operating characteristic(ROC)curves of serum BECN1 and SIRT6 levels were drawn.Results Compared with the control group,the serum BECN1 and SIRT6 levels were reduced in the STEMI group(both P<0.05).The incidence of IRI after PCI in 150 STEMI patients was 38.00%(57/150).Multifactorial Logistic regression analysis showed that increasing age(OR=1.094,95%CI:1.019 to 1.174)and increased albumin(OR=0.826,95%CI:0.723 to 0.943)and BECN1(OR=0.880,95%CI:0.830 to 0.933)and SIRT6(OR= 0.338,95%CI:0.204 to 0.558)were independent risk and protective factors for postoperative IRI in STE-MI patients(all P<0.05).ROC curve analysis showed that the area under the curve(AUC)of the combined serum BECN1 and SIRT6 levels(AUC=0.872,95%CI:0.808 to 0.921)in predicting postoperative IRI in STEMI patients was greater than that of BECN1(AUC=0.782,95%CI:0.707 to 0.845)or SIRT6(AUC= 0.783,95%CI:0.708 to 0.846)alone(both P<0.05).Conclusions Decreased serum BECN1 and SIRT6 levels in STEMI patients are closely related to postoperative IRI,which have a certain predictive value for postoperative IRI in STEMI patients.Serum BECN1 and SIRT6 levels are of high value in predicting postoperative IRI in STEMI patients,and may become auxiliary predictors of postoperative IRI in STEMI patients.关键词
ST段抬高型心肌梗死/苄氯素1/沉默信息调节因子6/经皮冠状动脉介入治疗/缺血再灌注损伤Key words
ST-segment elevation myocardial infarction/Beclin1/silent information regulator transcript 6/percu-taneous coronary intervention/ischemia-reperfusion injury分类
医药卫生引用本文复制引用
陈作强,李洲剑,衣帕尔古力·阿布拉,巩丽华,张慧敏..血清Beclin1、SIRT6水平与ST段抬高型心肌梗死患者PCI术后缺血再灌注损伤的关系[J].山东医药,2023,63(34):6-10,5.基金项目
中国管理科学研究院教育科学研究科教创新研究重点课题(KJCX9041) （KJCX9041）
巴音郭楞蒙古自治州人民医院院级科研项目(BY202304). （BY202304）
